F2RL1

Coagulation factor II (thrombin) receptor-like 1, also known as gene|F2RL1 or protease activated receptor 2 (PAR2), is a human gene.

PBB_Summary
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summary_text = Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [cite web | title = Entrez Gene: F2RL1 coagulation factor II (thrombin) receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2150| accessdate = ]

ee also

*Protease-activated receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kunzelmann K, Schreiber R, König J, Mall M |title=Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways. |journal=Cell Biochem. Biophys. |volume=36 |issue= 2-3 |pages= 209–14 |year= 2003 |pmid= 12139406 |doi=
*cite journal | author=Kawabata A |title=PAR-2: structure, function and relevance to human diseases of the gastric mucosa. |journal=Expert reviews in molecular medicine |volume=4 |issue= 16 |pages= 1–17 |year= 2004 |pmid= 14585156 |doi= 10.1017/S1462399402004799
*cite journal | author=Bushell T |title=The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders. |journal=J. Physiol. (Lond.) |volume=581 |issue= Pt 1 |pages= 7–16 |year= 2007 |pmid= 17347265 |doi= 10.1113/jphysiol.2007.129577
*cite journal | author=Nystedt S, Emilsson K, Larsson AK, "et al." |title=Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2. |journal=Eur. J. Biochem. |volume=232 |issue= 1 |pages= 84–9 |year= 1995 |pmid= 7556175 |doi=
*cite journal | author=Santulli RJ, Derian CK, Darrow AL, "et al." |title=Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 20 |pages= 9151–5 |year= 1995 |pmid= 7568091 |doi=
*cite journal | author=Nystedt S, Emilsson K, Wahlestedt C, Sundelin J |title=Molecular cloning of a potential proteinase activated receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 20 |pages= 9208–12 |year= 1994 |pmid= 7937743 |doi=
*cite journal | author=Mirza H, Yatsula V, Bahou WF |title=The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells. |journal=J. Clin. Invest. |volume=97 |issue= 7 |pages= 1705–14 |year= 1996 |pmid= 8601636 |doi=
*cite journal | author=Bohm SK, Kong W, Bromme D, "et al." |title=Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. |journal=Biochem. J. |volume=314 ( Pt 3) |issue= |pages= 1009–16 |year= 1996 |pmid= 8615752 |doi=
*cite journal | author=Böhm SK, Khitin LM, Grady EF, "et al." |title=Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22003–16 |year= 1996 |pmid= 8703006 |doi=
*cite journal | author=Kahn M, Ishii K, Kuo WL, "et al." |title=Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. |journal=Mol. Med. |volume=2 |issue= 3 |pages= 349–57 |year= 1996 |pmid= 8784787 |doi=
*cite journal | author=Molino M, Barnathan ES, Numerof R, "et al." |title=Interactions of mast cell tryptase with thrombin receptors and PAR-2. |journal=J. Biol. Chem. |volume=272 |issue= 7 |pages= 4043–9 |year= 1997 |pmid= 9020112 |doi=
*cite journal | author=Howells GL, Macey MG, Chinni C, "et al." |title=Proteinase-activated receptor-2: expression by human neutrophils. |journal=J. Cell. Sci. |volume=110 ( Pt 7) |issue= |pages= 881–7 |year= 1997 |pmid= 9133675 |doi=
*cite journal | author=D'Andrea MR, Derian CK, Leturcq D, "et al." |title=Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues. |journal=J. Histochem. Cytochem. |volume=46 |issue= 2 |pages= 157–64 |year= 1998 |pmid= 9446822 |doi=
*cite journal | author=Guyonnet Dupérat V, Jacquelin B, Boisseau P, "et al." |title=Protease-activated receptor genes are clustered on 5q13. |journal=Blood |volume=92 |issue= 1 |pages= 25–31 |year= 1998 |pmid= 9639495 |doi=
*cite journal | author=Steinhoff M, Corvera CU, Thoma MS, "et al." |title=Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. |journal=Exp. Dermatol. |volume=8 |issue= 4 |pages= 282–94 |year= 1999 |pmid= 10439226 |doi=
*cite journal | author=Takeuchi T, Harris JL, Huang W, "et al." |title=Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 26333–42 |year= 2000 |pmid= 10831593 |doi= 10.1074/jbc.M002941200
*cite journal | author=Loew D, Perrault C, Morales M, "et al." |title=Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry. |journal=Biochemistry |volume=39 |issue= 35 |pages= 10812–22 |year= 2000 |pmid= 10978167 |doi=
*cite journal | author=Knight DA, Lim S, Scaffidi AK, "et al." |title=Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. |journal=J. Allergy Clin. Immunol. |volume=108 |issue= 5 |pages= 797–803 |year= 2001 |pmid= 11692107 |doi= 10.1067/mai.2001.119025
*cite journal | author=Miike S, McWilliam AS, Kita H |title=Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6615–22 |year= 2002 |pmid= 11714832 |doi=
*cite journal | author=Asokananthan N, Graham PT, Fink J, "et al." |title=Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3577–85 |year= 2002 |pmid= 11907122 |doi=

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