GHB receptor

GHB receptor

Gamma-hydroxybutyrate receptor or GHB receptor is a receptor that binds gamma-Hydroxybutyric acid. Its existence was predicted by observing the action of its agonists that previously were thought to act on GABA-B receptors. cite journal |author=Snead OC |title=Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor |journal=J. Neurochem. |volume=75 |issue=5 |pages=1986–96 |year=2000 |month=November |pmid=11032888 |doi= |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0022-3042&date=2000&volume=75&issue=5&spage=1986 |issn=] The rat GHB receptor was first cloned and characterised in 2003 cite journal |author=Andriamampandry C, Taleb O, Viry S, "et al" |title=Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB) |journal=FASEB J. |volume=17 |issue=12 |pages=1691–3 |year=2003 |month=September |pmid=12958178 |doi=10.1096/fj.02-0846fje |url=http://www.fasebj.org/cgi/pmidlookup?view=long&pmid=12958178] followed by the human receptor in 2007. cite journal |author=Andriamampandry C, Taleb O, Kemmel V, Humbert JP, Aunis D, Maitre M |title=Cloning and functional characterization of a gamma-hydroxybutyrate receptor identified in the human brain |journal=FASEB J. |volume=21 |issue=3 |pages=885–95 |year=2007 |month=March |pmid=17197387 |doi=10.1096/fj.06-6509com |url=http://www.fasebj.org/cgi/pmidlookup?view=long&pmid=17197387] It is a G-protein coupled receptor.

See also

* gamma-Hydroxybutyric acid
* GPR172A

References


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