Growth hormone releasing hormone receptor

Growth hormone releasing hormone receptor

The growth hormone releasing hormone receptor (GHRHR) is a G-protein coupled receptor which binds growth hormone releasing hormone.cite journal | author = Gaylinn BD | title = Growth hormone releasing hormone receptor | journal = Recept. Channels | volume = 8 | issue = 3-4 | pages = 155–62 | year = 2002 | pmid = 12529933 | doi = 10.1080/10606820213679 | issn = ]

PBB_Summary
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summary_text = This gene, expressed in the pituitary, encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.cite web | title = Entrez Gene: GHRHR growth hormone releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2692| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gaylinn BD |title=Molecular and cell biology of the growth hormone-releasing hormone receptor. |journal=Growth Horm. IGF Res. |volume=9 Suppl A |issue= |pages= 37–44 |year= 1999 |pmid= 10429879 |doi=
*cite journal | author=Lin-Su K, Wajnrajch MP |title=Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor. |journal=Reviews in endocrine & metabolic disorders |volume=3 |issue= 4 |pages= 313–23 |year= 2003 |pmid= 12424433 |doi=
*cite journal | author=Mayo KE |title=Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone. |journal=Mol. Endocrinol. |volume=6 |issue= 10 |pages= 1734–44 |year= 1992 |pmid= 1333056 |doi=
*cite journal | author=Squire J, Zhou A, Hassel BA, "et al." |title=Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25. |journal=Genomics |volume=19 |issue= 1 |pages= 174–5 |year= 1994 |pmid= 7514564 |doi= 10.1006/geno.1994.1033
*cite journal | author=Hashimoto K, Koga M, Motomura T, "et al." |title=Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 10 |pages= 2933–9 |year= 1995 |pmid= 7559877 |doi=
*cite journal | author=Tang J, Lagacé G, Castagné J, Collu R |title=Identification of human growth hormone-releasing hormone receptor splicing variants. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 8 |pages= 2381–7 |year= 1995 |pmid= 7629234 |doi=
*cite journal | author=Gaylinn BD, Harrison JK, Zysk JR, "et al." |title=Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. |journal=Mol. Endocrinol. |volume=7 |issue= 1 |pages= 77–84 |year= 1993 |pmid= 7680413 |doi=
*cite journal | author=Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO |title=Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization. |journal=Genomics |volume=19 |issue= 1 |pages= 193–5 |year= 1994 |pmid= 8188233 |doi= 10.1006/geno.1994.1045
*cite journal | author=Wajnrajch MP, Gertner JM, Harbison MD, "et al." |title=Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse. |journal=Nat. Genet. |volume=12 |issue= 1 |pages= 88–90 |year= 1996 |pmid= 8528260 |doi= 10.1038/ng0196-88
*cite journal | author=Netchine I, Talon P, Dastot F, "et al." |title=Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 2 |pages= 432–6 |year= 1998 |pmid= 9467553 |doi=
*cite journal | author=Petersenn S, Rasch AC, Heyens M, Schulte HM |title=Structure and regulation of the human growth hormone-releasing hormone receptor gene. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 233–47 |year= 1998 |pmid= 9482665 |doi=
*cite journal | author=Maheshwari HG, Silverman BL, Dupuis J, Baumann G |title=Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 11 |pages= 4065–74 |year= 1998 |pmid= 9814493 |doi=
*cite journal | author=Salvatori R, Hayashida CY, Aguiar-Oliveira MH, "et al." |title=Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 3 |pages= 917–23 |year= 1999 |pmid= 10084571 |doi=
*cite journal | author=Morel G, Gallego R, Boulanger L, "et al." |title=Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries. |journal=Neuroendocrinology |volume=70 |issue= 2 |pages= 128–36 |year= 2000 |pmid= 10461027 |doi=
*cite journal | author=Rekasi Z, Czompoly T, Schally AV, Halmos G |title=Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 19 |pages= 10561–6 |year= 2000 |pmid= 10962031 |doi= 10.1073/pnas.180313297
*cite journal | author=Salvatori R, Fan X, Phillips JA, "et al." |title=Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 1 |pages= 273–9 |year= 2001 |pmid= 11232012 |doi=
*cite journal | author=Kiaris H, Schally AV, Busto R, "et al." |title=Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 196–200 |year= 2002 |pmid= 11773624 |doi= 10.1073/pnas.012590999
*cite journal | author=Salvatori R, Fan X, Mullis PE, "et al." |title=Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site. |journal=Mol. Endocrinol. |volume=16 |issue= 3 |pages= 450–8 |year= 2002 |pmid= 11875102 |doi=
*cite journal | author=Plonowski A, Schally AV, Busto R, "et al." |title=Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers. |journal=Peptides |volume=23 |issue= 6 |pages= 1127–33 |year= 2003 |pmid= 12126741 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2300 IUPHAR GPCR Database - GHRH receptor]
*

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