Niacin receptor 2

Hydroxycarboxylic acid receptor 3
Identifiers
Symbols	HCAR3; GPR109B; HCA3; HM74; PUMAG; Puma-g
External IDs	OMIM: 606039 HomoloGene: 55944 IUPHAR: GeneCards: HCAR3 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor protein signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8843	n/a
Ensembl	ENSG00000255398	n/a
UniProt	P49019	n/a
RefSeq (mRNA)	NP_006009	n/a
RefSeq (protein)	NM_006018	n/a
Location (UCSC)	Chr 12: 123.2 – 123.2 Mb	n/a
PubMed search	[1]	n/a

Niacin receptor 2, also known as NIACR2 or GPR109B, is a protein which in humans is encoded by the NIACR2 gene.^[1][2]

Function

GPR109B is a low affinity receptor for nicotinic acid (niacin)^[3] and is a member of the nicotinic acid receptor family of G protein-coupled receptors (the other identified member being GPR109A).

GPR109B is a G_i /G_o protein-coupled receptor with low affinity for nicotinic acid.^[3]

References

1. ^ "Entrez Gene: GPR109B G protein-coupled receptor 109B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8843. 
2. ^ Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
3. ^ ^{a b} Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB (March 2003). "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry 278 (11): 9869–74. doi:10.1074/jbc.M210695200. PMID 12522134. 

External links

• "Nicotinic Acid Receptor Family: GPR109B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3009. 

Further reading

• Nomura H, Nielsen BW, Matsushima K (1994). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.". Int. Immunol. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609. 
• Zingoni A, Rocchi M, Storlazzi CT, et al. (1997). "Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor.". Genomics 42 (3): 519–23. doi:10.1006/geno.1997.4754. PMID 9205127. 
• Irobi J, Nelis E, Verhoeven K, et al. (2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3.". J. Peripher. Nerv. Syst. 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wise A, Foord SM, Fraser NJ, et al. (2003). "Molecular identification of high and low affinity receptors for nicotinic acid.". J. Biol. Chem. 278 (11): 9869–74. doi:10.1074/jbc.M210695200. PMID 12522134. 
• Tunaru S, Kero J, Schaub A, et al. (2003). "PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect.". Nat. Med. 9 (3): 352–5. doi:10.1038/nm824. PMID 12563315. 
• Soga T, Kamohara M, Takasaki J, et al. (2003). "Molecular identification of nicotinic acid receptor.". Biochem. Biophys. Res. Commun. 303 (1): 364–9. doi:10.1016/S0006-291X(03)00342-5. PMID 12646212. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Toulza E, Mattiuzzo NR, Galliano MF, et al. (2007). "Large-scale identification of human genes implicated in epidermal barrier function.". Genome Biology 8 (6): R107. doi:10.1186/gb-2007-8-6-r107. PMC 2394760. PMID 17562024. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2394760.