P2RY11

Purinergic receptor P2Y, G-protein coupled, 11
Identifiers
Symbols	P2RY11; P2Y11
External IDs	OMIM: 602697 HomoloGene: 5690 GeneCards: P2RY11 Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • purinergic nucleotide receptor activity, G-protein coupled • ATP-activated nucleotide receptor activity Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • defense response • G-protein coupled receptor protein signaling pathway • activation of adenylate cyclase activity • activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger • calcium-mediated signaling • cellular response to ATP Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5032	235036
Ensembl	ENSG00000244165	ENSMUSG00000004100
UniProt	Q96G91	n/a
RefSeq (mRNA)	NM_002566	NM_145610.2
RefSeq (protein)	NP_002557	NP_663585.2
Location (UCSC)	Chr 19: 10.22 – 10.23 Mb	Chr 9: 20.69 – 20.7 Mb
PubMed search	[1]	[2]

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.^[1][2]

The product of this gene, P2Y₁₁, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.^[2]

See also

• P2Y receptor

References

1. ^ Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase". J Biol Chem 272 (51): 31969–73. doi:10.1074/jbc.272.51.31969. PMID 9405388. 
2. ^ ^{a b} "Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5032. 

External links

• "P2Y Receptors: P2Y₁₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2400. 

Further reading

• van der Weyden L, Conigrave AD, Morris MB (2000). "Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor". Immunol. Cell Biol. 78 (4): 369–74. doi:10.1046/j.1440-1711.2000.00918.x. PMID 10947861. 
• Adams MD, Kerlavage AR, Fleischmann RD et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf. 
• Communi D, Suarez-Huerta N, Dussossoy D et al. (2001). "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes". J. Biol. Chem. 276 (19): 16561–6. doi:10.1074/jbc.M009609200. PMID 11278528. 
• Moore DJ, Chambers JK, Wahlin JP et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642. 
• Duhant X, Schandené L, Bruyns C et al. (2002). "Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes". J. Immunol. 169 (1): 15–21. PMID 12077223. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Moreschi I, Bruzzone S, Nicholas RA et al. (2006). "Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes". J. Biol. Chem. 281 (42): 31419–29. doi:10.1074/jbc.M606625200. PMID 16926152. 
• Zylberg J, Ecke D, Fischer B, Reiser G (2007). "Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis". Biochem. J. 405 (2): 277–86. doi:10.1042/BJ20061728. PMC 1904521. PMID 17338680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1904521. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)