OPN1SW

Opsin 1 (cone pigments), short-wave-sensitive
Identifiers
Symbols	OPN1SW; BCP; BOP; CBT
External IDs	OMIM: 613522 MGI: 99438 HomoloGene: 1291 GeneCards: OPN1SW Gene
Gene Ontology Molecular function • receptor activity • G-protein coupled receptor activity • photoreceptor activity Cellular component • photoreceptor outer segment • plasma membrane • integral to plasma membrane Biological process • signal transduction • visual perception • phototransduction • protein-chromophore linkage • response to stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	611	12057
Ensembl	ENSG00000128617	ENSMUSG00000058831
UniProt	P03999	P51491
RefSeq (mRNA)	NM_001708	NM_007538.3
RefSeq (protein)	NP_001699	NP_031564.1
Location (UCSC)	Chr 7: 128.41 – 128.42 Mb	Chr 6: 29.33 – 29.33 Mb
PubMed search	[1]	[2]

Blue-sensitive opsin is a protein that in humans is encoded by the OPN1SW gene.^[1][2][3]

See also

• Opsin

References

1. ^ Nathans J, Thomas D, Hogness DS (Apr 1986). "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments". Science 232 (4747): 193–202. doi:10.1126/science.2937147. PMID 2937147. 
2. ^ Fitzgibbon J, Appukuttan B, Gayther S, Wells D, Delhanty J, Hunt DM (Feb 1994). "Localisation of the human blue cone pigment gene to chromosome band 7q31.3-32". Hum Genet 93 (1): 79–80. PMID 8270261. 
3. ^ "Entrez Gene: OPN1SW opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=611. 

Further reading

• Applebury ML, Hargrave PA (1987). "Molecular biology of the visual pigments.". Vision Res. 26 (12): 1881–95. doi:10.1016/0042-6989(86)90115-X. PMID 3303660. 
• Swanson WH, Cohen JM (2003). "Color vision.". Ophthalmology clinics of North America 16 (2): 179–203. doi:10.1016/S0896-1549(03)00004-X. PMID 12809157. 
• Weitz CJ, Went LN, Nathans J (1992). "Human tritanopia associated with a third amino acid substitution in the blue-sensitive visual pigment". Am. J. Hum. Genet. 51 (2): 444–6. PMC 1682686. PMID 1386496. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1682686. 
• Weitz CJ, Miyake Y, Shinzato K et al. (1992). "Human tritanopia associated with two amino acid substitutions in the blue-sensitive opsin". Am. J. Hum. Genet. 50 (3): 498–507. PMC 1684278. PMID 1531728. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1684278. 
• Oprian DD, Asenjo AB, Lee N, Pelletier SL (1992). "Design, chemical synthesis, and expression of genes for the three human color vision pigments". Biochemistry 30 (48): 11367–72. doi:10.1021/bi00112a002. PMID 1742276. 
• Sarkar G, Sommer SS (1989). "Access to a messenger RNA sequence or its protein product is not limited by tissue or species specificity". Science 244 (4902): 331–4. doi:10.1126/science.2565599. PMID 2565599. 
• Nathans J, Piantanida TP, Eddy RL et al. (1986). "Molecular genetics of inherited variation in human color vision". Science 232 (4747): 203–10. doi:10.1126/science.3485310. PMID 3485310. 
• Shimmin LC, Mai P, Li WH (1997). "Sequences and evolution of human and squirrel monkey blue opsin genes". J. Mol. Evol. 44 (4): 378–82. doi:10.1007/PL00006157. PMID 9089077. 
• Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Gunther KL, Neitz J, Neitz M (2006). "A novel mutation in the short-wavelength-sensitive cone pigment gene associated with a tritan color vision defect". Vis. Neurosci. 23 (3–4): 403–9. doi:10.1017/S0952523806233169. PMID 16961973. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)