CRYBB3

Crystallin, beta B3, also known as CRYBB3, is a human gene.cite web | title = Entrez Gene: CRYBB3 crystallin, beta B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1417| accessdate = ]

PBB_Summary
section_title =
summary_text = Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2.cite web | title = Entrez Gene: CRYBB3 crystallin, beta B3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1417| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Aarts HJ, Jacobs EH, van Willigen G, "et al." |title=Different evolution rates within the lens-specific beta-crystallin gene family. |journal=J. Mol. Evol. |volume=28 |issue= 4 |pages= 313–21 |year= 1989 |pmid= 2499686 |doi=
*cite journal | author=Kramer P, Yount J, Mitchell T, "et al." |title=A second gene for cerulean cataracts maps to the beta crystallin region on chromosome 22. |journal=Genomics |volume=35 |issue= 3 |pages= 539–42 |year= 1996 |pmid= 8812489 |doi= 10.1006/geno.1996.0395
*cite journal | author=Lampi KJ, Ma Z, Shih M, "et al." |title=Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2268–75 |year= 1997 |pmid= 8999933 |doi=
*cite journal | author=Kimoto Y |title=A possibility of all mRNA expression in a human single lymphocyte. |journal=Hum. Cell |volume=9 |issue= 4 |pages= 367–70 |year= 1997 |pmid= 9183670 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=MacCoss MJ, McDonald WH, Saraf A, "et al." |title=Shotgun identification of protein modifications from protein complexes and lens tissue. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 7900–5 |year= 2002 |pmid= 12060738 |doi= 10.1073/pnas.122231399
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Riazuddin SA, Yasmeen A, Yao W, "et al." |title=Mutations in betaB3-crystallin associated with autosomal recessive cataract in two Pakistani families. |journal=Invest. Ophthalmol. Vis. Sci. |volume=46 |issue= 6 |pages= 2100–6 |year= 2005 |pmid= 15914629 |doi= 10.1167/iovs.04-1481

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes