Coagulation factor II (thrombin) receptor-like 3
Symbols F2RL3; PAR4
External IDs OMIM602779 MGI1298207 HomoloGene36148 IUPHAR: PAR4 GeneCards: F2RL3 Gene
RNA expression pattern
PBB GE F2RL3 207221 at tn.png
More reference expression data
Species Human Mouse
Entrez 9002 14065
Ensembl ENSG00000127533 ENSMUSG00000050147
UniProt Q96RI0 Q0VDX1
RefSeq (mRNA) NM_003950 NM_007975.3
RefSeq (protein) NP_003941 NP_032001.2
Location (UCSC) Chr 19:
17 – 17 Mb
Chr 8:
75.29 – 75.29 Mb
PubMed search [1] [2]

Protease-activated receptor 4 (PAR4), previously known as Coagulation factor II (thrombin) receptor-like 3, is a protein encoded by the F2RL3 gene in humans.[1]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.[1]


See also


External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Metabolites and
signaling molecules
Class B: Secretin like Class C: Metabotropic
glutamate / pheromone Class F:
Frizzled / Smoothened
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Look at other dictionaries:

  • Protease-activated receptor — protein Name = coagulation factor II (thrombin) receptor caption = width = HGNCid = 3537 Symbol = F2R AltSymbols = PAR1 EntrezGene = 2149 OMIM = 187930 RefSeq = NM 001992 UniProt = P25116 PDB = ECnumber = Chromosome = 5 Arm = q Band = 13… …   Wikipedia

  • F2RL2 — Coagulation factor II (thrombin) receptor like 2 Identifiers Symbols F2RL2; PAR3 External IDs …   Wikipedia

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