Cannabinoid receptor 2 (macrophage)

Cannabinoid receptor 2 (macrophage), also known as CB2 or CNR2, is a human gene.cite web | title = Entrez Gene: CNR2 cannabinoid receptor 2 (macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1269| accessdate = ]

PBB_Summary
section_title =
summary_text = The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors.cite web | title = Entrez Gene: CNR2 cannabinoid receptor 2 (macrophage)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1269| accessdate = ]

elective Ligands

Several selective ligands for the CB₂ receptor are now available.

Agonists

* HU-308
* JWH-133
* L-759,633
* L-759,656

Antagonists and inverse agonists

* BML-190
* JTE-907

ee also

* Cannabinoid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Oddi S, Spagnuolo P, Bari M, "et al." |title=Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis. |journal=Int. Rev. Neurobiol. |volume=82 |issue= |pages= 327–37 |year= 2007 |pmid= 17678969 |doi= 10.1016/S0074-7742(07)82017-4
*cite journal | author=Galiègue S, Mary S, Marchand J, "et al." |title=Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. |journal=Eur. J. Biochem. |volume=232 |issue= 1 |pages= 54–61 |year= 1995 |pmid= 7556170 |doi=
*cite journal | author=Munro S, Thomas KL, Abu-Shaar M |title=Molecular characterization of a peripheral receptor for cannabinoids. |journal=Nature |volume=365 |issue= 6441 |pages= 61–5 |year= 1993 |pmid= 7689702 |doi= 10.1038/365061a0
*cite journal | author=Shire D, Calandra B, Rinaldi-Carmona M, "et al." |title=Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. |journal=Biochim. Biophys. Acta |volume=1307 |issue= 2 |pages= 132–6 |year= 1996 |pmid= 8679694 |doi=
*cite journal | author=Tao Q, McAllister SD, Andreassi J, "et al." |title=Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. |journal=Mol. Pharmacol. |volume=55 |issue= 3 |pages= 605–13 |year= 1999 |pmid= 10051546 |doi=
*cite journal | author=Nong L, Newton C, Friedman H, Klein TW |title=CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types. |journal=Adv. Exp. Med. Biol. |volume=493 |issue= |pages= 229–33 |year= 2002 |pmid= 11727770 |doi=
*cite journal | author=Ho BY, Current L, Drewett JG |title=Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16). |journal=FEBS Lett. |volume=522 |issue= 1-3 |pages= 130–4 |year= 2002 |pmid= 12095632 |doi=
*cite journal | author=Matias I, Pochard P, Orlando P, "et al." |title=Presence and regulation of the endocannabinoid system in human dendritic cells. |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3771–8 |year= 2002 |pmid= 12153574 |doi=
*cite journal | author=Song ZH, Feng W |title=Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function. |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 290–4 |year= 2002 |pmid= 12417328 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Casanova ML, Blázquez C, Martínez-Palacio J, "et al." |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. |journal=J. Clin. Invest. |volume=111 |issue= 1 |pages= 43–50 |year= 2003 |pmid= 12511587 |doi=
*cite journal | author=Feng W, Song ZH |title=Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor. |journal=Biochem. Pharmacol. |volume=65 |issue= 7 |pages= 1077–85 |year= 2003 |pmid= 12663043 |doi=
*cite journal | author=Kishimoto S, Gokoh M, Oka S, "et al." |title=2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24469–75 |year= 2003 |pmid= 12711605 |doi= 10.1074/jbc.M301359200
*cite journal | author=Jorda MA, Rayman N, Valk P, "et al." |title=Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2. |journal=Ann. N. Y. Acad. Sci. |volume=996 |issue= |pages= 10–6 |year= 2003 |pmid= 12799277 |doi=
*cite journal | author=Benito C, Núñez E, Tolón RM, "et al." |title=Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. |journal=J. Neurosci. |volume=23 |issue= 35 |pages= 11136–41 |year= 2003 |pmid= 14657172 |doi=
*cite journal | author=Rayman N, Lam KH, Laman JD, "et al." |title=Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status. |journal=J. Immunol. |volume=172 |issue= 4 |pages= 2111–7 |year= 2004 |pmid= 14764676 |doi=
*cite journal | author=Rao GK, Zhang W, Kaminski NE |title=Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells. |journal=J. Leukoc. Biol. |volume=75 |issue= 5 |pages= 884–92 |year= 2004 |pmid= 14966196 |doi= 10.1189/jlb.1203638
*cite journal | author=Alberich Jordà M, Rayman N, Tas M, "et al." |title=The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner. |journal=Blood |volume=104 |issue= 2 |pages= 526–34 |year= 2004 |pmid= 15039279 |doi= 10.1182/blood-2003-12-4357
*cite journal | author=Núñez E, Benito C, Pazos MR, "et al." |title=Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. |journal=Synapse |volume=53 |issue= 4 |pages= 208–13 |year= 2004 |pmid= 15266552 |doi= 10.1002/syn.20050
*cite journal | author=Gokoh M, Kishimoto S, Oka S, "et al." |title=2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells. |journal=Biochem. J. |volume=386 |issue= Pt 3 |pages= 583–9 |year= 2005 |pmid= 15456404 |doi= 10.1042/BJ20041163

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