Leukotriene B4 receptor 2

Leukotriene B4 receptor 2

Leukotriene B4 receptor 2, also known as LTB4R2, is a human gene.cite web | title = Entrez Gene: LTB4R2 leukotriene B4 receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56413| accessdate = ]

This is a low-affinity receptor for leukotrienes, especially leukotriene B4. It mediates chemotaxis of granulocytes and macrophages.

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ee also

* Eicosanoid receptor

References

Further reading

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*cite journal | author=Tager AM, Luster AD |title=BLT1 and BLT2: the leukotriene B(4) receptors. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=69 |issue= 2-3 |pages= 123–34 |year= 2004 |pmid= 12895595 |doi=
*cite journal | author=Kamohara M, Takasaki J, Matsumoto M, "et al." |title=Molecular cloning and characterization of another leukotriene B4 receptor. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27000–4 |year= 2000 |pmid= 10889186 |doi= 10.1074/jbc.C000382200
*cite journal | author=Tryselius Y, Nilsson NE, Kotarsky K, "et al." |title=Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 2 |pages= 377–82 |year= 2000 |pmid= 10913346 |doi= 10.1006/bbrc.2000.3152
*cite journal | author=Nilsson NE, Tryselius Y, Owman C |title=Genomic organization of the leukotriene B(4) receptor locus of human chromosome 14. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 2 |pages= 383–8 |year= 2000 |pmid= 10913347 |doi= 10.1006/bbrc.2000.3153
*cite journal | author=Kato K, Yokomizo T, Izumi T, Shimizu T |title=Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 413–20 |year= 2000 |pmid= 10934229 |doi=
*cite journal | author=Yokomizo T, Kato K, Terawaki K, "et al." |title=A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 421–32 |year= 2000 |pmid= 10934230 |doi=
*cite journal | author=Wang S, Gustafson E, Pang L, "et al." |title=A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 40686–94 |year= 2001 |pmid= 11006272 |doi= 10.1074/jbc.M004512200
*cite journal | author=Takeda S, Kadowaki S, Haga T, "et al." |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97–101 |year= 2002 |pmid= 12044878 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hashimoto A, Endo H, Hayashi I, "et al." |title=Differential expression of leukotriene B4 receptor subtypes (BLT1 and BLT2) in human synovial tissues and synovial fluid leukocytes of patients with rheumatoid arthritis. |journal=J. Rheumatol. |volume=30 |issue= 8 |pages= 1712–8 |year= 2003 |pmid= 12913925 |doi=
*cite journal | author=Yoo MH, Song H, Woo CH, "et al." |title=Role of the BLT2, a leukotriene B4 receptor, in Ras transformation. |journal=Oncogene |volume=23 |issue= 57 |pages= 9259–68 |year= 2005 |pmid= 15489890 |doi= 10.1038/sj.onc.1208151
*cite journal | author=Qiu H, Johansson AS, Sjöström M, "et al." |title=Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 18 |pages= 6913–8 |year= 2006 |pmid= 16624877 |doi= 10.1073/pnas.0602208103
*cite journal | author=Lundeen KA, Sun B, Karlsson L, Fourie AM |title=Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells. |journal=J. Immunol. |volume=177 |issue= 5 |pages= 3439–47 |year= 2006 |pmid= 16920986 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1289 IUPHAR GPCR Database - Leukotriene receptors]
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