Cysteinyl leukotriene receptor 1

Cysteinyl leukotriene receptor 1
Identifiers
Symbols	CYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81; MGC46139
External IDs	OMIM: 300201 MGI: 1926218 HomoloGene: 4837 IUPHAR: CysLT1 GeneCards: CYSLTR1 Gene
Gene Ontology Molecular function • receptor activity • leukotriene receptor activity Cellular component • membrane fraction • plasma membrane • plasma membrane • integral to plasma membrane Biological process • calcium ion transport • chemotaxis • defense response • inflammatory response • elevation of cytosolic calcium ion concentration • respiratory gaseous exchange • positive regulation of vasoconstriction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10800	58861
Ensembl	ENSG00000173198	ENSMUSG00000052821
UniProt	Q9Y271	Q544P1
RefSeq (mRNA)	NM_006639	NM_021476.4
RefSeq (protein)	NP_006630	NP_067451.2
Location (UCSC)	Chr X: 77.53 – 77.58 Mb	Chr X: 103.77 – 103.8 Mb
PubMed search	[1]	[2]

Cysteinyl leukotriene receptor 1 is a protein that in humans is encoded by the CYSLTR1 gene.^[1][2][3]

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.^[3]

See also

• Eicosanoid receptor

References

1. ^ Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF (Jul 1999). "Characterization of the human cysteinyl leukotriene CysLT1 receptor". Nature 399 (6738): 789–93. doi:10.1038/21658. PMID 10391245. 
2. ^ Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW (Sep 1999). "Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor". Mol Pharmacol 56 (3): 657–63. PMID 10462554. 
3. ^ ^{a b} "Entrez Gene: CYSLTR1 cysteinyl leukotriene receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10800. 

External links

• "Leukotriene Receptors: CysLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2343. 

Further reading

• Gronert K, Martinsson-Niskanen T, Ravasi S, et al. (2001). "Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.". Am. J. Pathol. 158 (1): 3–9. doi:10.1016/S0002-9440(10)63937-5. PMC 1850279. PMID 11141472. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850279. 
• Sjöström M, Jakobsson PJ, Heimburger M, et al. (2001). "Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor.". Eur. J. Biochem. 268 (9): 2578–86. doi:10.1046/j.1432-1327.2001.02142.x. PMID 11322876. 
• Mellor EA, Maekawa A, Austen KF, Boyce JA (2001). "Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells.". Proc. Natl. Acad. Sci. U.S.A. 98 (14): 7964–9. doi:10.1073/pnas.141221498. PMC 35451. PMID 11438743. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=35451. 
• Mita H, Hasegawa M, Saito H, Akiyama K (2002). "Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils.". Clin. Exp. Allergy 31 (11): 1714–23. doi:10.1046/j.1365-2222.2001.01184.x. PMID 11696047. 
• Shirasaki H, Kanaizumi E, Watanabe K, et al. (2003). "Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa.". Clin. Exp. Allergy 32 (7): 1007–12. doi:10.1046/j.1365-2222.2002.01425.x. PMID 12100046. 
• Ohshima N, Nagase H, Koshino T, et al. (2002). "A functional study on CysLT(1) receptors in human eosinophils.". Int. Arch. Allergy Immunol. 129 (1): 67–75. doi:10.1159/000065175. PMID 12373000. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ohd JF, Nielsen CK, Campbell J, et al. (2003). "Expression of the leukotriene D4 receptor CysLT1, COX-2, and other cell survival factors in colorectal adenocarcinomas.". Gastroenterology 124 (1): 57–70. doi:10.1053/gast.2003.50011. PMID 12512030. 
• Chibana K, Ishii Y, Asakura T, Fukuda T (2003). "Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin.". J. Immunol. 170 (8): 4290–5. PMID 12682264. 
• Espinosa K, Bossé Y, Stankova J, Rola-Pleszczynski M (2003). "CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4.". J. Allergy Clin. Immunol. 111 (5): 1032–40. doi:10.1067/mai.2003.1451. PMID 12743568. 
• Walch L, Norel X, Gascard JP, Brink C (2003). "Arachidonic acid inhibits cysteinyl-leukotriene receptor activation in human pulmonary vessels.". Adv. Exp. Med. Biol. 525: 75–9. PMID 12751740. 
• Nielsen CK, Ohd JF, Wikström K, et al. (2003). "The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.". Adv. Exp. Med. Biol. 525: 201–4. PMID 12751768. 
• Mechiche H, Naline E, Candenas L, et al. (2003). "Effects of cysteinyl leukotrienes in small human bronchus and antagonist activity of montelukast and its metabolites.". Clin. Exp. Allergy 33 (7): 887–94. doi:10.1046/j.1365-2222.2003.01696.x. PMID 12859443. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Yang G, Haczku A, Chen H, et al. (2004). "Transgenic smooth muscle expression of the human CysLT1 receptor induces enhanced responsiveness of murine airways to leukotriene D4.". Am. J. Physiol. Lung Cell Mol. Physiol. 286 (5): L992–1001. doi:10.1152/ajplung.00367.2003. PMID 15064240. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Naik S, Billington CK, Pascual RM, et al. (2005). "Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling.". J. Biol. Chem. 280 (10): 8722–32. doi:10.1074/jbc.M413014200. PMID 15590629. 
• Corrigan C, Mallett K, Ying S, et al. (2005). "Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis.". J. Allergy Clin. Immunol. 115 (2): 316–22. doi:10.1016/j.jaci.2004.10.051. PMID 15696087. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)