Neuromedin U receptor 2

Neuromedin U receptor 2
Identifiers
Symbols	NMUR2; FM-4; FM4; NMU-R2; NMU2R; TGR-1; TGR1
External IDs	OMIM: 605108 MGI: 2441765 HomoloGene: 49618 IUPHAR: NMU2 GeneCards: NMUR2 Gene
Gene Ontology Molecular function • neuromedin U receptor activity • receptor activity • G-protein coupled receptor activity • intracellular calcium activated chloride channel activity • GTP binding • neuromedin U binding Cellular component • plasma membrane • plasma membrane • integral to membrane Biological process • reduction of food intake in response to dietary excess • calcium ion transport • regulation of smooth muscle contraction • activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger • elevation of cytosolic calcium ion concentration • neuropeptide signaling pathway • cell-cell signaling • central nervous system development • grooming behavior • feeding behavior • transmission of nerve impulse • calcium-mediated signaling • activation of phospholipase A2 activity by calcium-mediated signaling • inositol phosphate-mediated signaling • response to pain • arachidonic acid secretion • response to protein stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56923	216749
Ensembl	ENSG00000132911	ENSMUSG00000037393
UniProt	Q9GZQ4	Q8BZ39
RefSeq (mRNA)	NM_020167	NM_153079.4
RefSeq (protein)	NP_064552	NP_694719.2
Location (UCSC)	Chr 5: 151.77 – 151.81 Mb	Chr 11: 55.84 – 55.85 Mb
PubMed search	[1]	[2]

Neuromedin-U receptor 2 is a protein that in humans is encoded by the NMUR2 gene.^[1][2][3]

See also

• Neuromedin U receptor

References

1. ^ Tate CG, Grisshammer R (Jan 1997). "Heterologous expression of G-protein-coupled receptors". Trends Biotechnol 14 (11): 426–30. doi:10.1016/0167-7799(96)10059-7. PMID 8940772. 
2. ^ Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q (Jul 2000). "Identification of receptors for neuromedin U and its role in feeding". Nature 406 (6791): 70–4. doi:10.1038/35017610. PMID 10894543. 
3. ^ "Entrez Gene: NMUR2 neuromedin U receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56923. 

External links

• "Neuromedin U Receptors: NMU2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2899. 

Further reading

• Hosoya M, Moriya T, Kawamata Y, et al. (2000). "Identification and functional characterization of a novel subtype of neuromedin U receptor.". J. Biol. Chem. 275 (38): 29528–32. doi:10.1074/jbc.M004261200. PMID 10887190. 
• Raddatz R, Wilson AE, Artymyshyn R, et al. (2000). "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.". J. Biol. Chem. 275 (42): 32452–9. doi:10.1074/jbc.M004613200. PMID 10899166. 
• Shan L, Qiao X, Crona JH, et al. (2001). "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system.". J. Biol. Chem. 275 (50): 39482–6. doi:10.1074/jbc.C000522200. PMID 11010960. 
• Fernández Alvarez C, Debeljuk L, Díaz Rodríguez E, Díaz López B (2003). "Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin.". Peptides 23 (9): 1617–23. doi:10.1016/S0196-9781(02)00099-2. PMID 12217422. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Bhattacharyya S, Luan J, Farooqi IS, et al. (2004). "Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.". J. Endocrinol. 183 (1): 115–20. doi:10.1677/joe.1.05830. PMID 15525579. 
• Mori K, Miyazato M, Ida T, et al. (2005). "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system.". EMBO J. 24 (2): 325–35. doi:10.1038/sj.emboj.7600526. PMC 545815. PMID 15635449. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545815. 
• Fang L, Zhang M, Li C, et al. (2006). "Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.". Neurosci. Lett. 404 (1–2): 148–53. doi:10.1016/j.neulet.2006.05.034. PMID 16781063. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)