Relaxin/insulin-like family peptide receptor 2

Relaxin/insulin-like family peptide receptor 2, also known as RXFP2, is a human gene.cite web | title = Entrez Gene: RXFP2 relaxin/insulin-like family peptide receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=122042| accessdate = ]

PBB_Summary
section_title =
summary_text = The receptors for glycoprotein hormones such as follicle-stimulating hormone (FSH; see MIM 136530) and thyroid-stimulating hormone (TSH; see MIM 188540) are G protein-coupled, 7-transmembrane receptors (GPCRs) with large N-terminal extracellular domains. Leucine-rich repeat (LRR)-containing GPCRs (LGRs) form a subgroup of the GPCR superfamily. [supplied by OMIM] cite web | title = Entrez Gene: RXFP2 relaxin/insulin-like family peptide receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=122042| accessdate = ]

ee also

* Relaxin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bathgate RA, Ivell R, Sanborn BM, "et al." |title=Receptors for relaxin family peptides. |journal=Ann. N. Y. Acad. Sci. |volume=1041 |issue= |pages= 61–76 |year= 2005 |pmid= 15956688 |doi= 10.1196/annals.1282.010
*cite journal | author=Bathgate RA, Ivell R, Sanborn BM, "et al." |title=International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. |journal=Pharmacol. Rev. |volume=58 |issue= 1 |pages= 7–31 |year= 2006 |pmid= 16507880 |doi= 10.1124/pr.58.1.9
*cite journal | author=Hsu SY, Nakabayashi K, Nishi S, "et al." |title=Activation of orphan receptors by the hormone relaxin. |journal=Science |volume=295 |issue= 5555 |pages= 671–4 |year= 2002 |pmid= 11809971 |doi= 10.1126/science.1065654
*cite journal | author=Kumagai J, Hsu SY, Matsumi H, "et al." |title=INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31283–6 |year= 2002 |pmid= 12114498 |doi= 10.1074/jbc.C200398200
*cite journal | author=Gorlov IP, Kamat A, Bogatcheva NV, "et al." |title=Mutations of the GREAT gene cause cryptorchidism. |journal=Hum. Mol. Genet. |volume=11 |issue= 19 |pages= 2309–18 |year= 2003 |pmid= 12217959 |doi=
*cite journal | author=Sudo S, Kumagai J, Nishi S, "et al." |title=H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 7855–62 |year= 2003 |pmid= 12506116 |doi= 10.1074/jbc.M212457200
*cite journal | author=Ferlin A, Simonato M, Bartoloni L, "et al." |title=The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 9 |pages= 4273–9 |year= 2003 |pmid= 12970298 |doi=
*cite journal | author=Roh J, Virtanen H, Kumagai J, "et al." |title=Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism. |journal=Reprod. Biomed. Online |volume=7 |issue= 4 |pages= 400–6 |year= 2004 |pmid= 14656401 |doi=
*cite journal | author=Vinci G, Anjot MN, Trivin C, "et al." |title=An analysis of the genetic factors involved in testicular descent in a cohort of 14 male patients with anorchia. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 12 |pages= 6282–5 |year= 2005 |pmid= 15579790 |doi= 10.1210/jc.2004-0891
*cite journal | author=Büllesbach EE, Schwabe C |title=LGR8 signal activation by the relaxin-like factor. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 14586–90 |year= 2005 |pmid= 15708846 |doi= 10.1074/jbc.M414443200
*cite journal | author=Muda M, He C, Martini PG, "et al." |title=Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity. |journal=Mol. Hum. Reprod. |volume=11 |issue= 8 |pages= 591–600 |year= 2005 |pmid= 16051677 |doi= 10.1093/molehr/gah205
*cite journal | author=Rosengren KJ, Zhang S, Lin F, "et al." |title=Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3. |journal=J. Biol. Chem. |volume=281 |issue= 38 |pages= 28287–95 |year= 2006 |pmid= 16867980 |doi= 10.1074/jbc.M603829200
*cite journal | author=Bogatcheva NV, Ferlin A, Feng S, "et al." |title=T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=292 |issue= 1 |pages= E138–44 |year= 2007 |pmid= 16926383 |doi= 10.1152/ajpendo.00228.2006
*cite journal | author=Scott DJ, Layfield S, Yan Y, "et al." |title=Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. |journal=J. Biol. Chem. |volume=281 |issue= 46 |pages= 34942–54 |year= 2007 |pmid= 16963451 |doi= 10.1074/jbc.M602728200
*cite journal | author=El Houate B, Rouba H, Sibai H, "et al." |title=Novel mutations involving the INSL3 gene associated with cryptorchidism. |journal=J. Urol. |volume=177 |issue= 5 |pages= 1947–51 |year= 2007 |pmid= 17437853 |doi= 10.1016/j.juro.2007.01.002
*cite journal | author=Scott DJ, Wilkinson TN, Zhang S, "et al." |title=Defining the LGR8 residues involved in binding insulin-like peptide 3. |journal=Mol. Endocrinol. |volume=21 |issue= 7 |pages= 1699–712 |year= 2007 |pmid= 17473281 |doi= 10.1210/me.2007-0097

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