Bradykinin receptor

Bradykinin receptor

protein
Name = bradykinin receptor B1
caption =


width =
HGNCid = 1029
Symbol = BDKRB1
AltSymbols =
EntrezGene = 623
OMIM = 600337
RefSeq = NM_000710
UniProt = P46663
PDB =
ECnumber =
Chromosome = 14
Arm = q
Band = 32.1
LocusSupplementaryData = -32.2protein
Name = bradykinin receptor B2
caption =


width =
HGNCid = 1030
Symbol = BDKRB2
AltSymbols =
EntrezGene = 624
OMIM = 113503
RefSeq = NM_000623
UniProt = P30411
PDB =
ECnumber =
Chromosome = 14
Arm = q
Band = 32.1
LocusSupplementaryData = -32.2The bradykinin receptor is a receptor for bradykinin.

There are two Bradykinin receptors: the B1 receptor and the B2 receptor.cite journal | author = Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BL | title = International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences | journal = Pharmacol. Rev. | volume = 57 | issue = 1 | pages = 27–77 | year = 2005 | pmid = 15734727 | doi = 10.1124/pr.57.1.2 | issn = ]

B2 receptor

The B2 receptor is a G protein-coupled receptor, coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.cite journal | author = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = | issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 ]

Ictibant is a second generation B2 receptor antagonist which has undergone limited clinical trials in pain and inflammation.

Kallidin also signals through the B2 receptor.

References

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1330 IUPHAR GPCR Database - Bradykinin Receptor family]
*


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