GPR3

G protein-coupled receptor 3, also known as GPR3, is a human gene.cite web | title = Entrez Gene: GPR3 G protein-coupled receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2827| accessdate = ] cite journal | author = Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF | title = Cloning of human genes encoding novel G protein-coupled receptors | journal = Genomics | volume = 23 | issue = 3 | pages = 609–18 | year = 1994 | month = October | pmid = 7851889 | doi = 10.1006/geno.1994.1549 | url = | issn = ] The protein encoded by this gene is a member of the G protein-coupled receptor family of transmembrane receptors and is involved in signal transduction.

Function

GPR3 activates adenylate cyclase in the absence of ligand.cite journal | author = Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F | title = Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase | journal = Biochem. J. | volume = 309 ( Pt 3) | issue = | pages = 837–43 | year = 1995 | month = August | pmid = 7639700 | pmc = 1135708 | url = | issn = ] GPR3 is expressed in mammalian oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue.cite journal |author = Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA |title = The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes | journal = Science (journal) |volume = 306 | issue = 5703 | pages = 1947–50 | year = 2004 | month = December | pmid = 15591206 | doi = 10.1126/science.1103974 | url = | issn = ] While GPR3 have a certain level of constitutive activity, it is believed that sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are ligands that further activate the receptor.cite journal | author = Hinckley M, Vaccari S, Horner K, Chen R, Conti M | title = The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes | journal = Dev. Biol. | volume = 287 | issue = 2 | pages = 249–61 | year = 2005 | month = November | pmid = 16229830 | doi = 10.1016/j.ydbio.2005.08.019 | url = | issn = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Eggerickx D, Denef JF, Labbe O, "et al." |title=Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. |journal=Biochem. J. |volume=309 ( Pt 3) |issue= |pages= 837–43 |year= 1995 |pmid= 7639700 |doi=
*cite journal | author=Iismaa TP, Kiefer J, Liu ML, "et al." |title=Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system. |journal=Genomics |volume=24 |issue= 2 |pages= 391–4 |year= 1995 |pmid= 7698767 |doi= 10.1006/geno.1994.1635
*cite journal | author=Heiber M, Docherty JM, Shah G, "et al." |title=Isolation of three novel human genes encoding G protein-coupled receptors. |journal=DNA Cell Biol. |volume=14 |issue= 1 |pages= 25–35 |year= 1995 |pmid= 7832990 |doi=
*cite journal | author=Marchese A, Docherty JM, Nguyen T, "et al." |title=Cloning of human genes encoding novel G protein-coupled receptors. |journal=Genomics |volume=23 |issue= 3 |pages= 609–18 |year= 1995 |pmid= 7851889 |doi= 10.1006/geno.1994.1549
*cite journal | author=Song ZH, Modi W, Bonner TI |title=Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. |journal=Genomics |volume=28 |issue= 2 |pages= 347–9 |year= 1996 |pmid= 8530049 |doi= 10.1006/geno.1995.1154
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Uhlenbrock K, Huber J, Ardati A, "et al." |title=Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. |journal=Cell. Physiol. Biochem. |volume=13 |issue= 2 |pages= 75–84 |year= 2003 |pmid= 12649592 |doi= 10.1159/000070251
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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