[cite web | title = Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5733| accessdate = ] ] PBB_Summary
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Receptor
The receptor is a member of the G-protein coupled receptor family. It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.
Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.
Variations
Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.[cite web | title = Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5733| accessdate = ] ]ee also
* Eicosanoid receptor
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kotani M, Tanaka I, Ogawa Y, "et al." |title=Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions. |journal=Mol. Pharmacol. |volume=48 |issue= 5 |pages= 869–79 |year= 1995 |pmid= 7476918 |doi=
*cite journal | author=Duncan AM, Anderson LL, Funk CD, "et al." |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740–2 |year= 1995 |pmid= 7759114 |doi=
*cite journal | author=Schmid A, Thierauch KH, Schleuning WD, Dinter H |title=Splice variants of the human EP3 receptor for prostaglandin E2. |journal=Eur. J. Biochem. |volume=228 |issue= 1 |pages= 23–30 |year= 1995 |pmid= 7883006 |doi=
*cite journal | author=An S, Yang J, So SW, "et al." |title=Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals. |journal=Biochemistry |volume=33 |issue= 48 |pages= 14496–502 |year= 1995 |pmid= 7981210 |doi=
*cite journal | author=Regan JW, Bailey TJ, Donello JE, "et al." |title=Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini. |journal=Br. J. Pharmacol. |volume=112 |issue= 2 |pages= 377–85 |year= 1994 |pmid= 8075855 |doi=
*cite journal | author=Yang J, Xia M, Goetzl EJ, An S |title=Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. |journal=Biochem. Biophys. Res. Commun. |volume=198 |issue= 3 |pages= 999–1006 |year= 1994 |pmid= 8117308 |doi=
*cite journal | author=Kunapuli SP, Fen Mao G, Bastepe M, "et al." |title=Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells. |journal=Biochem. J. |volume=298 ( Pt 2) |issue= |pages= 263–7 |year= 1994 |pmid= 8135729 |doi=
*cite journal | author=Adam M, Boie Y, Rushmore TH, "et al." |title=Cloning and expression of three isoforms of the human EP3 prostanoid receptor. |journal=FEBS Lett. |volume=338 |issue= 2 |pages= 170–4 |year= 1994 |pmid= 8307176 |doi=
*cite journal | author=Chang C, Negishi M, Nishigaki N, Ichikawa A |title=Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype. |journal=Biochem. J. |volume=322 ( Pt 2) |issue= |pages= 597–601 |year= 1997 |pmid= 9065782 |doi=
*cite journal | author=Kotani M, Tanaka I, Ogawa Y, "et al." |title=Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3). |journal=Genomics |volume=40 |issue= 3 |pages= 425–34 |year= 1997 |pmid= 9073510 |doi= 10.1006/geno.1996.4585
*cite journal | author=Ushikubi F, Segi E, Sugimoto Y, "et al." |title=Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. |journal=Nature |volume=395 |issue= 6699 |pages= 281–4 |year= 1998 |pmid= 9751056 |doi= 10.1038/26233
*cite journal | author=Bhattacharya M, Peri K, Ribeiro-da-Silva A, "et al." |title=Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15719–24 |year= 1999 |pmid= 10336471 |doi=
*cite journal | author=Liu J, Akahoshi T, Jiang S, "et al." |title=Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3. |journal=J. Leukoc. Biol. |volume=68 |issue= 2 |pages= 187–93 |year= 2000 |pmid= 10947062 |doi=
*cite journal | author=Kurihara Y, Endo H, Kondo H |title=Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells. |journal=Inflamm. Res. |volume=50 |issue= 1 |pages= 1–5 |year= 2001 |pmid= 11235015 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuoka Y, Furuyashiki T, Bito H, "et al." |title=Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4132–7 |year= 2003 |pmid= 12642666 |doi= 10.1073/pnas.0633341100
*cite journal | author=Wing DA, Goharkhay N, Hanna M, "et al." |title=EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium. |journal=J. Soc. Gynecol. Investig. |volume=10 |issue= 3 |pages= 124–9 |year= 2003 |pmid= 12699873 |doi=
*cite journal | author=Abulencia JP, Gaspard R, Healy ZR, "et al." |title=Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28388–94 |year= 2003 |pmid= 12743126 |doi= 10.1074/jbc.M301378200
*cite journal | author=Richards JA, Brueggemeier RW |title=Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2810–6 |year= 2003 |pmid= 12788892 |doi=
*cite journal | author=Moreland RB, Kim N, Nehra A, "et al." |title=Functional prostaglandin E (EP) receptors in human penile corpus cavernosum. |journal=Int. J. Impot. Res. |volume=15 |issue= 5 |pages= 362–8 |year= 2004 |pmid= 14562138 |doi= 10.1038/sj.ijir.3901042
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