- Prostaglandin F2alpha
-
This article is about the pharmaceutical agent 'dinoprost'. For the drug 'dinoprostone', see Prostaglandin E2.
Dinoprost Tromethamine Systematic (IUPAC) name (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)- 3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid Clinical data AHFS/Drugs.com International Drug Names Pregnancy cat. ? Legal status ? Routes Intravenous (to induce labor), intra-amniotic (to induce abortion) Pharmacokinetic data Half-life 3 to 6 hours in amniotic fluid, less than 1 minute in blood plasma Identifiers CAS number 551-11-1 38562-01-5
ATC code G02AD01 PubChem CID 5280363 IUPHAR ligand 1884 DrugBank DB01160 ChemSpider 4445570 KEGG D01352 ChEMBL CHEMBL815 Chemical data Formula C20H34O5 Mol. mass 354.48 g/mol (what is this?) F2alpha (verify)
Prostaglandin F2α (PGF2α in prostanoid nomenclature) is pharmaceutically termed Dinoprost (INN) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
In domestic mammals, it is produced by the uterus when stimulated by oxytocin, in the event that there has been no implantation during the follicular phase. It acts on the corpus luteum to cause luteolysis, forming a corpus albicans and stopping the production of progesterone. Action of PGF2α is dependent on the number of receptors on the corpus luteum membrane.
The PGF2α isoform 8-iso-PGF2α was found in significantly increased amounts in patients with endometriosis, thus being a potential causative link in endometriosis-associated oxidative stress.[1]
Mechanism of action
Further information: Prostaglandin F2α receptorPGF2α acts by binding to the prostaglandin F2α receptor.it is also commercially available as (Enzaprost)
References
- ^ Sharma, I.; Dhaliwal, L.; Saha, S.; Sangwan, S.; Dhawan, V. (2010). "Role of 8-iso-prostaglandin F2alpha and 25-hydroxycholesterol in the pathophysiology of endometriosis". Fertility and sterility 94 (1): 63–70. doi:10.1016/j.fertnstert.2009.01.141. PMID 19324352.
Precursor Prostanoids PrecursorActiveD/JE/FE2 (Dinoprostone): Enprostil · Sulprostone
E1 (Alprostadil): Misoprostol · Gemeprost
F2α (Dinoprost): Bimatoprost · Carboprost · Latanoprost · Tafluprost · Travoprost · UnoprostoneIThromboxanes (TX)Leukotrienes (LT) PrecursorInitialSRS-ANonclassic By function biochemical families: prot · nucl · carb (glpr, alco, glys) · lipd (fata/i, phld, strd, gllp, eico) · amac/i · ncbs/i · ttpy/iUterotonics/labor inducers/oxytocics (G02A) Cervical ripening Ergot alkaloidsE: Misoprostol/E1# • Gemeprost/E1 • Dinoprostone/E2 • Sulprostone/E2
F: Dinoprost/F2α • Carboprost/F2αContraction induction Categories:- Abortifacients
- Prostaglandins
- Medicine stubs
Wikimedia Foundation. 2010.