Bimatoprost

drugbox
IUPAC_name = 7- [3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl] -"N"-ethyl-hept-5-enamide

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CAS_number = 155206-00-1
ATC_prefix = S01
ATC_suffix = EE03
ATC_supplemental =
PubChem = 5311027
DrugBank = APRD00826
C = 25 | H = 37 | N = 1 | O = 4
molecular_weight = 415.566 g/mol
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routes_of_administration = Topical (eye drops)

Bimatoprost (sold in the U.S. and Canada by Allergan, under the trade name Lumigan) is a prostamide used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes.cite web | url = http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602030.html | title = Bimatoprost Ophthalmic | publisher = MedlinePlus | date = January 1 2003 | accessdate = 2007-11-19] It has also been used and prescribed off-label to lengthen eyelashes. [cite news | title=Drug That Lengthens Eyelashes Sets Off Flutter | url=http://online.wsj.com/article/SB119543055372597359.html | date=2007-11-19 | work = The Wall Street Journal | accessdate=2007-11-19]

Cosmetic use

In patients using ophthalmic prostaglandins such as travoprost and latanoprost, as well as prostamides like bimatoprost, it has been anecdotally noted that they have grown long and lush eyelashes. Allergan has initiated clinical trials investigating the usage of Lumigan as a cosmetic drug. Wall Street Journal: [http://online.wsj.com/article/SB119543055372597359.html?mod=googlenews_wsj Drug That Lengthens Eyelashes Sets Off Flutter] "RHONDA L. RUNDLE" November 19, 2007; Page B1 ]

Several cosmetics companies have released products based on a prostaglandin analogs, as non-drug cosmetics.
* Age Intervention Eyelash and Age Intervention Eyelash by Jan Marini Skin Research
* RevitaLash by Athena Cosmetics Corp.
* MD Lash Factor by PhotoMedex Inc.These companies have been sued by Allergan for patent infringment. The FDA has seized "Age Intervention Eyelash" as an "unapproved and misbranded drug" because "Jan Marini Skin Research" promoted it as something that increases eyelash growth MSNBC: [http://www.msnbc.msn.com/id/21842238/ FDA Seizes $2 Million Of Potentially Harmful SJ Eye Product] "KNTV-TV" 2:44 p.m. ET, Sat., Nov. 17, 2007 ] and because it is "adulterated" with bimatoprost. Reuters: [http://www.reuters.com/article/domesticNews/idUSN1642077420071117 U.S. seizes discontinued eyelash product] "Jim Wolf" Fri Nov 16, 2007 11:48pm EST ]

Formulations

Lumigan is a 0.03% solution of bimatoprost, and contains benzalkonium chloride as a preservative. Contact lenses should therefore be removed before use, and replaced no less than 15 minutes later; other eye drops or ointments should be given no less than 5 minutes before or after bimatoprost. It is administered once daily.

ide effects

Possible side effects of this medication are:
* May cause blurred vision;
* May cause eyelid redness;
* May permanently darken eyelashes;
* May cause eye discomfort;
* May eventually cause permanent darkening of the iris to brown (heterochromia).
* May cause a temporary burning sensation during use.
* May cause thickening of the eyelashes.

On November 19 2007 the FDA issued a warning during the seizure of a bimatoprost-containing cosmetic. [cite press release | url = http://www.fda.gov/consumer/updates/cosmeticeye111907.html | title = Potentially Harmful "Cosmetic" Eye Product Seized | date = November 19 2007 | accessdate = 2007-12-05 | publisher = U.S. Food and Drug Administration] . The warning stated that "the extra dose of bimatoprost may decrease the prescription drug's effectiveness. Damage to the optic nerve may lead to decreased vision and possibly blindness."

References

Citations

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External links

* Medical News Today: [http://www.medicalnewstoday.com/articles/89146.php FDA Seizes $2 Million Of Cosmetic Eye Product Which Contains Drug Ingredient And Makes Unapproved Drug Claims] "Christian Nordqvist" 18 Nov 2007 - 11:00 PST
* Wired Science: [http://blog.wired.com/wiredscience/2007/11/fda-seizes-cosm.html FDA Seizes Cosmetic That Can Blind] "Brandon Keim" November 19, 2007 11:00:00 AM