- Prostaglandin analogue
Synthetic prostaglandin analogues are molecules which are manufactured to bind to a
prostaglandin receptor .Wider use of prostaglandin analogues is limited by unwanted side effects and their abortive potential.
Uses
* Prostaglandin analogues such as
misoprostol are used in treatment of duodenal and gastric ulcers. They exert antisecretory and cytoprotective properties and are especially indicated for theelderly on continuous doses ofNSAID s.* Prostaglandin analogues can also be used in the management of open-angle
glaucoma . They reduce intra-ocular pressure by enhancing uveoscleral outflow and may also have some effect on thetrabecular meshwork as well.Latanoprost ,travoprost ,unoprostone andbimatoprost are examples of prostaglandin analogues used in the management of open-angle glaucoma. In some countries such as Australia, they are now considered first line agents in open-angle glaucoma (rather thanbeta blocker s) [AMH 2008: Australian Medicines Handbook, 9th Edition Adelaide, S. Aust. : Australian Medicines Handbook, c2008., ]References
External links
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