Beraprost

Beraprost

Drugbox
IUPAC_name = 2,3,3"a",8"b"-tetrahydro-2-hydroxy-1-(3-hydroxy-4-
methyl-1-octen-6-ynyl)-1"H"-cyclopenta("b")benzofuran-
5-butanoic acid


width = 250
CAS_number=88430-50-6
CAS_supplemental=CAS|88475-69-8 (sodium salt)
ATC_prefix=B01
ATC_suffix=AC19
PubChem=5282428
DrugBank=
C = 24 | H = 30 | O = 5
molecular_weight = 398.492 g/mol
bioavailability= 50–70%
metabolism = Unknown
elimination_half-life= 35–40 minutes
pregnancy_category =
routes_of_administration= Oral
excretion = ?
legal_status = ?

Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

Clinical pharmacology

As an analogue of prostacyclin PGI2, beraprost effects vasodilation, which in turn lowers the blood pressure. Beraprost also inhibits platelet aggregation, though the role this phenomenon may play in relation to pulmonary hypertension has yet to be determined.

Dosage and administration

Beraprost is administered orally as a pill.


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