Prostaglandin D2 synthase

Prostaglandin D2 synthase

Prostaglandin D2 synthase 21kDa (brain), also known as PTGDS, is a human gene.cite web | title = Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5730| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.cite web | title = Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5730| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=White DM, Mikol DD, Espinosa R, "et al." |title=Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase. |journal=J. Biol. Chem. |volume=267 |issue= 32 |pages= 23202–8 |year= 1992 |pmid= 1385416 |doi=
*cite journal | author=Kuruvilla AP, Hochwald GM, Ghiso J, "et al." |title=Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid. |journal=Brain Res. |volume=565 |issue= 2 |pages= 337–40 |year= 1993 |pmid= 1726844 |doi=
*cite journal | author=Nagata A, Suzuki Y, Igarashi M, "et al." |title=Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 4020–4 |year= 1991 |pmid= 1902577 |doi=
*cite journal | author=Zahn M, Mäder M, Schmidt B, "et al." |title=Purification and N-terminal sequence of beta-trace, a protein abundant in human cerebrospinal fluid. |journal=Neurosci. Lett. |volume=154 |issue= 1-2 |pages= 93–5 |year= 1993 |pmid= 7689714 |doi=
*cite journal | author=Harrington MG, Aebersold R, Martin BM, "et al." |title=Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein. |journal=Appl. Theor. Electrophor. |volume=3 |issue= 5 |pages= 229–34 |year= 1993 |pmid= 7692978 |doi=
*cite journal | author=Bastien L, Sawyer N, Grygorczyk R, "et al." |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873–7 |year= 1994 |pmid= 8163486 |doi=
*cite journal | author=Funk CD, Furci L, FitzGerald GA, "et al." |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767–72 |year= 1994 |pmid= 8253813 |doi=
*cite journal | author=Abramovitz M, Boie Y, Nguyen T, "et al." |title=Cloning and expression of a cDNA for the human prostanoid FP receptor. |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 2632–6 |year= 1994 |pmid= 8300593 |doi=
*cite journal | author=Hoffmann A, Conradt HS, Gross G, "et al." |title=Purification and chemical characterization of beta-trace protein from human cerebrospinal fluid: its identification as prostaglandin D synthase. |journal=J. Neurochem. |volume=61 |issue= 2 |pages= 451–6 |year= 1993 |pmid= 8336134 |doi=
*cite journal | author=Leone MG, Saso L, Del Vecchio A, "et al." |title=Micropurification of two human cerebrospinal fluid proteins by high performance electrophoresis chromatography. |journal=J. Neurochem. |volume=61 |issue= 2 |pages= 533–40 |year= 1993 |pmid= 8336140 |doi=
*cite journal | author=Giacomelli S, Leone MG, Grima J, "et al." |title=Astrocytes synthesize and secrete prostaglandin D synthetase in vitro. |journal=Biochim. Biophys. Acta |volume=1310 |issue= 3 |pages= 269–76 |year= 1996 |pmid= 8599604 |doi=
*cite journal | author=Blödorn B, Mäder M, Urade Y, "et al." |title=Choroid plexus: the major site of mRNA expression for the beta-trace protein (prostaglandin D synthase) in human brain. |journal=Neurosci. Lett. |volume=209 |issue= 2 |pages= 117–20 |year= 1996 |pmid= 8761996 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Yamashima T, Sakuda K, Tohma Y, "et al." |title=Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. |journal=J. Neurosci. |volume=17 |issue= 7 |pages= 2376–82 |year= 1999 |pmid= 9065498 |doi=
*cite journal | author=White DM, Takeda T, DeGroot LJ, "et al." |title=Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14387–93 |year= 1997 |pmid= 9162076 |doi=
*cite journal | author=Eguchi Y, Eguchi N, Oda H, "et al." |title=Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14689–94 |year= 1998 |pmid= 9405674 |doi=
*cite journal | author=Tokugawa Y, Kunishige I, Kubota Y, "et al." |title=Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. |journal=Biol. Reprod. |volume=58 |issue= 2 |pages= 600–7 |year= 1998 |pmid= 9475419 |doi=
*cite journal | author=Saso L, Leone MG, Sorrentino C, "et al." |title=Quantification of prostaglandin D synthetase in cerebrospinal fluid: a potential marker for brain tumor. |journal=Biochem. Mol. Biol. Int. |volume=46 |issue= 4 |pages= 643–56 |year= 1999 |pmid= 9844724 |doi=
*cite journal | author=Blödorn B, Brück W, Tumani H, "et al." |title=Expression of the beta-trace protein in human pachymeninx as revealed by in situ hybridization and immunocytochemistry. |journal=J. Neurosci. Res. |volume=57 |issue= 5 |pages= 730–4 |year= 1999 |pmid= 10462696 |doi=
*cite journal | author=Pinzar E, Kanaoka Y, Inui T, "et al." |title=Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4903–7 |year= 2000 |pmid= 10781097 |doi= 10.1073/pnas.090093997

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