Prostaglandin-D synthase

In enzymology, a prostaglandin-D synthase (EC number|5.3.99.2) is an enzyme that catalyzes the chemical reaction

:(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate $ightleftharpoons$ (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate

Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- and dienoate, whereas its product is (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

This enzyme belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase. Other names in common use include prostaglandin-H2 Delta-isomerase, prostaglandin-R-prostaglandin D isomerase, and PGH-PGD isomerase. This enzyme participates in arachidonic acid metabolism.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1IYH, PDB link|1IYI, PDB link|1PD2, PDB link|1V40, PDB link|2CZT, PDB link|2CZU, and PDB link|2E4J.

References

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* Sri Kantha,S. Prostaglandin D syntha (beta-trace protein) - a molecular clock to trace the origin of REM sleep? "Medical Hypotheses", 1997; 48: 411-412.

External links

::"The CAS registry number for this enzyme class is CAS registry|65802-85-9."

Gene Ontology (GO) codes