NPR2

Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
Identifiers
Symbols	NPR2; AMDM; ANPRB; ANPb; GUC2B; GUCY2B; NPRB; NPRBi
External IDs	OMIM: 108961 MGI: 97372 HomoloGene: 2970 GeneCards: NPR2 Gene
EC number	4.6.1.2
Gene Ontology Molecular function • nucleotide binding • guanylate cyclase activity • protein kinase activity • receptor activity • transmembrane receptor activity • ATP binding • GTP binding • transferase activity, transferring phosphorus-containing groups • natriuretic peptide receptor activity • peptide hormone binding • hormone binding • identical protein binding Cellular component • membrane fraction • plasma membrane • integral to membrane Biological process • ossification • cGMP biosynthetic process • signal transduction • cell surface receptor linked signaling pathway • receptor guanylyl cyclase signaling pathway • regulation of blood pressure • intracellular signal transduction • bone development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4882	230103
Ensembl	ENSG00000159899	ENSMUSG00000028469
UniProt	P20594	Q6VVW5
RefSeq (mRNA)	NM_003995	NM_173788.3
RefSeq (protein)	NP_003986	NP_776149.1
Location (UCSC)	Chr 9: 35.79 – 35.81 Mb	Chr 4: 43.64 – 43.66 Mb
PubMed search	[1]	[2]

Natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B), also known as NPR2, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR2 gene.^[1]

See also

• Atrial natriuretic peptide receptor

References

1. ^ "Entrez Gene: NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4882. 

Further reading

• Fox AA, Collard CD, Shernan SK, et al. (2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.". Anesthesiology 110 (4): 738–47. doi:10.1097/ALN.0b013e31819c7496. PMC 2735337. PMID 19326473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2735337. 
• Potthast R, Abbey-Hosch SE, Antos LK, et al. (2004). "Calcium-dependent dephosphorylation mediates the hyperosmotic and lysophosphatidic acid-dependent inhibition of natriuretic peptide receptor-B/guanylyl cyclase-B.". J. Biol. Chem. 279 (47): 48513–9. doi:10.1074/jbc.M408247200. PMID 15371450. 
• Liew D, Schneider H, D'Agostino J, et al. (2004). "Utility of B-type natriuretic peptide as a screen for left ventricular dysfunction in patients with diabetes: response to Epshteyn et al.". Diabetes Care 27 (3): 848; author reply 848–9. doi:10.2337/diacare.27.3.848. PMID 14988324. 
• Antos LK, Abbey-Hosch SE, Flora DR, Potter LR (2005). "ATP-independent activation of natriuretic peptide receptors.". J. Biol. Chem. 280 (29): 26928–32. doi:10.1074/jbc.M505648200. PMID 15911610. 
• Poreba R, Poczatek K, Gać P, et al. (2009). "SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension.". Pol. Arch. Med. Wewn. 119 (4): 219–24. PMID 19413180. 
• Koller KJ, Goeddel DV (1992). "Molecular biology of the natriuretic peptides and their receptors.". Circulation 86 (4): 1081–8. PMID 1327579. 
• Fan D, Bryan PM, Antos LK, et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.". Mol. Pharmacol. 67 (1): 174–83. doi:10.1124/mol.104.002436. PMID 15459247. 
• Pagel-Langenickel I, Buttgereit J, Bader M, Langenickel TH (2007). "Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy.". J. Mol. Med. 85 (8): 797–810. doi:10.1007/s00109-007-0183-4. PMID 17429599. 
• Rahmutula D, Cui J, Chen S, Gardner DG (2004). "Transcriptional regulation of type B human natriuretic Peptide receptor gene promoter: dependence on Sp1.". Hypertension 44 (3): 283–8. doi:10.1161/01.HYP.0000136908.60317.92. PMID 15262909. 
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• Hume AN, Buttgereit J, Al-Awadhi AM, et al. (2009). "Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux.". Hum. Mol. Genet. 18 (2): 267–77. doi:10.1093/hmg/ddn354. PMC 2638773. PMID 18945719. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2638773. 
• Schulz S (2005). "C-type natriuretic peptide and guanylyl cyclase B receptor.". Peptides 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070. 
• Tsuji T, Kunieda T (2005). "A loss-of-function mutation in natriuretic peptide receptor 2 (Npr2) gene is responsible for disproportionate dwarfism in cn/cn mouse.". J. Biol. Chem. 280 (14): 14288–92. doi:10.1074/jbc.C500024200. PMID 15722353. 
• Dickey DM, Yoder AR, Potter LR (2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.". J. Biol. Chem. 284 (29): 19196–202. doi:10.1074/jbc.M109.010777. PMC 2740543. PMID 19458086. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2740543. 
• Nozohoor S, Nilsson J, Lührs C, et al. (2009). "B-type natriuretic peptide as a predictor of postoperative heart failure after aortic valve replacement.". J. Cardiothorac. Vasc. Anesth. 23 (2): 161–5. doi:10.1053/j.jvca.2008.11.006. PMID 19167912. 
• Hachiya R, Ohashi Y, Kamei Y, et al. (2007). "Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development.". J. Clin. Endocrinol. Metab. 92 (10): 4009–14. doi:10.1210/jc.2007-1101. PMID 17652215. 
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Bartels CF, Bükülmez H, Padayatti P, et al. (2004). "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux.". Am. J. Hum. Genet. 75 (1): 27–34. doi:10.1086/422013. PMC 1182004. PMID 15146390. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1182004. 
• van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors.". J. Mol. Biol. 311 (5): 923–37. doi:10.1006/jmbi.2001.4922. PMID 11556325. 

External links

• MeSH NPR2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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