NTRK3

Neurotrophic tyrosine kinase, receptor, type 3, also known as NTRK3, is a human gene.

PBB_Summary
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summary_text = This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.cite web | title = Entrez Gene: NTRK3 neurotrophic tyrosine kinase, receptor, type 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4916| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ebendal T |title=Function and evolution in the NGF family and its receptors. |journal=J. Neurosci. Res. |volume=32 |issue= 4 |pages= 461–70 |year= 1992 |pmid= 1326636 |doi= 10.1002/jnr.490320402
*cite journal | author=Lamballe F, Klein R, Barbacid M |title=trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. |journal=Cell |volume=66 |issue= 5 |pages= 967–79 |year= 1991 |pmid= 1653651 |doi=10.1016/0092-8674(91)90442-2
*cite journal | author=Guiton M, Gunn-Moore FJ, Glass DJ, "et al." |title=Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling. |journal=J. Biol. Chem. |volume=270 |issue= 35 |pages= 20384–90 |year= 1995 |pmid= 7657612 |doi=10.1074/jbc.270.35.20384
*cite journal | author=McGregor LM, Baylin SB, Griffin CA, "et al." |title=Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. |journal=Genomics |volume=22 |issue= 2 |pages= 267–72 |year= 1995 |pmid= 7806211 |doi= 10.1006/geno.1994.1383
*cite journal | author=Shelton DL, Sutherland J, Gripp J, "et al." |title=Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. |journal=J. Neurosci. |volume=15 |issue= 1 Pt 2 |pages= 477–91 |year= 1995 |pmid= 7823156 |doi=
*cite journal | author=Pflug BR, Dionne C, Kaplan DR, "et al." |title=Expression of a Trk high affinity nerve growth factor receptor in the human prostate. |journal=Endocrinology |volume=136 |issue= 1 |pages= 262–8 |year= 1995 |pmid= 7828539 |doi=10.1210/en.136.1.262
*cite journal | author=Lamballe F, Tapley P, Barbacid M |title=trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. |journal=Embo J. |volume=12 |issue= 8 |pages= 3083–94 |year= 1993 |pmid= 8344249 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yamamoto M, Sobue G, Yamamoto K, "et al." |title=Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. |journal=Neurochem. Res. |volume=21 |issue= 8 |pages= 929–38 |year= 1997 |pmid= 8895847 |doi=10.1007/BF02532343
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Valent A, Danglot G, Bernheim A |title=Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 2 |pages= 102–4 |year= 1997 |pmid= 9195161 |doi=
*cite journal | author=Terenghi G, Mann D, Kopelman PG, Anand P |title=trkA and trkC expression is increased in human diabetic skin. |journal=Neurosci. Lett. |volume=228 |issue= 1 |pages= 33–6 |year= 1997 |pmid= 9197281 |doi=10.1016/S0304-3940(97)00350-9
*cite journal | author=Knezevich SR, McFadden DE, Tao W, "et al." |title=A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. |journal=Nat. Genet. |volume=18 |issue= 2 |pages= 184–7 |year= 1998 |pmid= 9462753 |doi= 10.1038/ng0298-184
*cite journal | author=Urfer R, Tsoulfas P, O'Connell L, "et al." |title=High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5829–40 |year= 1998 |pmid= 9488719 |doi=10.1074/jbc.273.10.5829
*cite journal | author=Hu YQ, Koo PH |title=Inhibition of phosphorylation of TrkB and TrkC and their signal transduction by alpha2-macroglobulin. |journal=J. Neurochem. |volume=71 |issue= 1 |pages= 213–20 |year= 1998 |pmid= 9648868 |doi=
*cite journal | author=Ichaso N, Rodriguez RE, Martin-Zanca D, Gonzalez-Sarmiento R |title=Genomic characterization of the human trkC gene. |journal=Oncogene |volume=17 |issue= 14 |pages= 1871–5 |year= 1998 |pmid= 9778053 |doi= 10.1038/sj.onc.1202100
*cite journal | author=Qian X, Riccio A, Zhang Y, Ginty DD |title=Identification and characterization of novel substrates of Trk receptors in developing neurons. |journal=Neuron |volume=21 |issue= 5 |pages= 1017–29 |year= 1999 |pmid= 9856458 |doi=10.1016/S0896-6273(00)80620-0
*cite journal | author=Bibel M, Hoppe E, Barde YA |title=Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. |journal=Embo J. |volume=18 |issue= 3 |pages= 616–22 |year= 1999 |pmid= 9927421 |doi= 10.1093/emboj/18.3.616
*cite journal | author=Labouyrie E, Dubus P, Groppi A, "et al." |title=Expression of neurotrophins and their receptors in human bone marrow. |journal=Am. J. Pathol. |volume=154 |issue= 2 |pages= 405–15 |year= 1999 |pmid= 10027399 |doi=

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