- STAT5A
Signal transducer and activator of transcription 5A, also known as STAT5A, is a human
gene .PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [cite web | title = Entrez Gene: STAT5A signal transducer and activator of transcription 5A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6776| accessdate = ]ee also
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STAT5 References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1–24 |year= 2002 |pmid= 12039028 |doi=
*cite journal | author=Buitenhuis M, Coffer PJ, Koenderman L |title=Signal transducer and activator of transcription 5 (STAT5). |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 11 |pages= 2120–4 |year= 2005 |pmid= 15313458 |doi= 10.1016/j.biocel.2003.11.008PBB_Controls
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