MAPK1

Mitogen-activated protein kinase 1
PDB rendering based on 1erk.
Available structures PDB 1PME, 1TVO, 1WZY, 2E14, 2OJG, 2OJI, 2OJJ, 3D42, 3D44, 3I5Z, 3I60
Identifiers
Symbols	MAPK1; ERK; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk
External IDs	OMIM: 176948 MGI: 1346858 HomoloGene: 37670 GeneCards: MAPK1 Gene
EC number	2.7.11.24
Gene Ontology Molecular function • nucleotide binding • phosphotyrosine binding • DNA binding • protein serine/threonine kinase activity • MAP kinase activity • protein binding • ATP binding • transcription factor binding • RNA polymerase II carboxy-terminal domain kinase activity • kinase activity • kinase activity • phosphatase binding • mitogen-activated protein kinase kinase kinase binding Cellular component • soluble fraction • insoluble fraction • nucleus • nucleoplasm • nucleoplasm • cytoplasm • cytosol • cytosol • dendrite cytoplasm • axon part • perikaryon • protein complex Biological process • MAPKKK cascade • activation of MAPKK activity • activation of MAPK activity • MAPK import into nucleus • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • induction of apoptosis • chemotaxis • response to stress • response to DNA damage stimulus • cell cycle • signal transduction • epidermal growth factor receptor signaling pathway • small GTPase mediated signal transduction • Ras protein signal transduction • synaptic transmission • axon guidance • blood coagulation • Toll signaling pathway • positive regulation of cell proliferation • insulin receptor signaling pathway • response to toxin • organ morphogenesis • phosphorylation • sensory perception of pain • cytosine metabolic process • platelet activation • positive regulation of cell migration • lipopolysaccharide-mediated signaling pathway • response to lipopolysaccharide • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • response to exogenous dsRNA • response to estrogen stimulus • interspecies interaction between organisms • innate immune response • negative regulation of cell differentiation • positive regulation of translation • nerve growth factor receptor signaling pathway • T cell receptor signaling pathway • B cell receptor signaling pathway • regulation of sequence-specific DNA binding transcription factor activity • stress-activated MAPK cascade • labyrinthine layer blood vessel development • ERK1 and ERK2 cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5594	26413
Ensembl	ENSG00000100030	ENSMUSG00000063358
UniProt	P28482	Q3UF82
RefSeq (mRNA)	NM_002745.4	NM_001038663
RefSeq (protein)	NP_002736.3	NP_001033752
Location (UCSC)	Chr 22: 22.11 – 22.22 Mb	Chr 16: 16.98 – 17.05 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.^[1]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.^[2]

Interactions

MAPK1 has been shown to interact with TSC2,^[3] PEA15,^[4] DUSP1,^[5][6] NEK2,^[7] DUSP3,^[8] STAT5A,^[9][10] MAPK14,^[11][12] FHL2,^[13] TNIP1,^[14] RPS6KA3,^[15][16] RPS6KA2,^[15][17] MAP2K1,^{[11][18][19][20][21][22]} RPS6KA1,^[16][17][23] PTPN7,^[24][25] MKNK1,^[26] CIITA,^[27] TOB1,^[28] Phosphatidylethanolamine binding protein 1,^[19] DUSP22,^[29] Myc,^[30][31][32] ADAM17,^[33] SORBS3,^[34] ELK1,^[23][35] VAV1,^[36][37] HDAC4,^[38] MKNK2,^[26][39] MAP3K1^[40] and UBR5.^[23]

See also

• Extracellular signal-regulated kinases

References

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2. ^ "Entrez Gene: MAPK1 mitogen-activated protein kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5594. 
3. ^ Ma, Li; Chen Zhenbang, Erdjument-Bromage Hediye, Tempst Paul, Pandolfi Pier Paolo (Apr. 2005). "Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis". Cell (United States) 121 (2): 179–93. doi:10.1016/j.cell.2005.02.031. ISSN 0092-8674. PMID 15851026. 
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External Links

• MAP Kinase Resource .

Further reading

• Morishima-Kawashima M, Hasegawa M, Takio K, et al. (1995). "Hyperphosphorylation of tau in PHF". Neurobiol. Aging 16 (3): 365–71; discussion 371–80. doi:10.1016/0197-4580(95)00027-C. PMID 7566346. 
• Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977. 
• Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2): 91–6. doi:10.1080/13550280290167885. PMID 12491158. 
• Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410. 
• Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene 26 (22): 3227–39. doi:10.1038/sj.onc.1210414. PMID 17496918.