Mitogen-activated protein kinase 1

PDB rendering based on 1erk.
Symbols MAPK1; ERK; ERK2; ERT1; MAPK2; P42MAPK; PRKM1; PRKM2; p38; p40; p41; p41mapk
External IDs OMIM176948 MGI1346858 HomoloGene37670 GeneCards: MAPK1 Gene
EC number
RNA expression pattern
PBB GE MAPK1 212271 at.png
PBB GE MAPK1 208351 s at.png
More reference expression data
Species Human Mouse
Entrez 5594 26413
Ensembl ENSG00000100030 ENSMUSG00000063358
UniProt P28482 Q3UF82
RefSeq (mRNA) NM_002745.4 NM_001038663
RefSeq (protein) NP_002736.3 NP_001033752
Location (UCSC) Chr 22:
22.11 – 22.22 Mb
Chr 16:
16.98 – 17.05 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.[1]



The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.[2]


MAPK1 has been shown to interact with TSC2,[3] PEA15,[4] DUSP1,[5][6] NEK2,[7] DUSP3,[8] STAT5A,[9][10] MAPK14,[11][12] FHL2,[13] TNIP1,[14] RPS6KA3,[15][16] RPS6KA2,[15][17] MAP2K1,[11][18][19][20][21][22] RPS6KA1,[16][17][23] PTPN7,[24][25] MKNK1,[26] CIITA,[27] TOB1,[28] Phosphatidylethanolamine binding protein 1,[19] DUSP22,[29] Myc,[30][31][32] ADAM17,[33] SORBS3,[34] ELK1,[23][35] VAV1,[36][37] HDAC4,[38] MKNK2,[26][39] MAP3K1[40] and UBR5.[23]

See also


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  2. ^ "Entrez Gene: MAPK1 mitogen-activated protein kinase 1". 
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  5. ^ Slack, D N; Seternes O M, Gabrielsen M, Keyse S M (May. 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". J. Biol. Chem. (United States) 276 (19): 16491–500. doi:10.1074/jbc.M010966200. ISSN 0021-9258. PMID 11278799. 
  6. ^ Calvisi, Diego F; Pinna Federico, Meloni Floriana, Ladu Sara, Pellegrino Rossella, Sini Marcella, Daino Lucia, Simile Maria M, De Miglio Maria R, Virdis Patrizia, Frau Maddalena, Tomasi Maria L, Seddaiu Maria A, Muroni Maria R, Feo Francesco, Pascale Rosa M (Jun. 2008). "Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma". Cancer Res. (United States) 68 (11): 4192–200. doi:10.1158/0008-5472.CAN-07-6157. PMID 18519678. 
  7. ^ Lou, Yang; Xie Wei, Zhang Dong-Fang, Yao Jian-hui, Luo Zhao-feng, Wang Yu-Zhen, Shi Yun-Yu, Yao Xue-Biao (Aug. 2004). "Nek2A specifies the centrosomal localization of Erk2". Biochem. Biophys. Res. Commun. (United States) 321 (2): 495–501. doi:10.1016/j.bbrc.2004.06.171. ISSN 0006-291X. PMID 15358203. 
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  14. ^ Zhang, Shengliang; Fukushi Masaya, Hashimoto Shinichi, Gao Chongfeng, Huang Lin, Fukuyo Yayoi, Nakajima Takuma, Amagasa Teruo, Enomoto Shoji, Koike Katsuro, Miura Osamu, Yamamoto Naoki, Tsuchida Nobuo (Sep. 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochem. Biophys. Res. Commun. (United States) 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. ISSN 0006-291X. PMID 12220502. 
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External Links

Further reading

  • Morishima-Kawashima M, Hasegawa M, Takio K, et al. (1995). "Hyperphosphorylation of tau in PHF". Neurobiol. Aging 16 (3): 365–71; discussion 371–80. doi:10.1016/0197-4580(95)00027-C. PMID 7566346. 
  • Davis RJ (1996). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. doi:10.1002/mrd.1080420414. PMID 8607977. 
  • Peruzzi F, Gordon J, Darbinian N, Amini S (2003). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2): 91–6. doi:10.1080/13550280290167885. PMID 12491158. 
  • Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. doi:10.1007/BF02970151. PMID 12734410. 
  • Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene 26 (22): 3227–39. doi:10.1038/sj.onc.1210414. PMID 17496918. 

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