PRKAG1

Protein kinase, AMP-activated, gamma 1 non-catalytic subunit, also known as PRKAG1, is a human gene.cite web | title = Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5571| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.cite web | title = Entrez Gene: PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5571| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hofmann B, Nishanian P, Baldwin RL, "et al." |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=
*cite journal | author=Beebe SJ, Oyen O, Sandberg M, "et al." |title=Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. |journal=Mol. Endocrinol. |volume=4 |issue= 3 |pages= 465–75 |year= 1990 |pmid= 2342480 |doi=
*cite journal | author=Hofmann B, Nishanian P, Nguyen T, "et al." |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=
*cite journal | author=Hofmann B, Nishanian P, Fan J, "et al." |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=
*cite journal | author=Stapleton D, Mitchelhill KI, Gao G, "et al." |title=Mammalian AMP-activated protein kinase subfamily. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 611–4 |year= 1996 |pmid= 8557660 |doi=
*cite journal | author=Gao G, Fernandez CS, Stapleton D, "et al." |title=Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8675–81 |year= 1996 |pmid= 8621499 |doi=
*cite journal | author=Woods A, Cheung PC, Smith FC, "et al." |title=Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro. |journal=J. Biol. Chem. |volume=271 |issue= 17 |pages= 10282–90 |year= 1996 |pmid= 8626596 |doi=
*cite journal | author=Dyck JR, Gao G, Widmer J, "et al." |title=Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 17798–803 |year= 1996 |pmid= 8663446 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Swingler S, Gallay P, Camaur D, "et al." |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi=
*cite journal | author=Stapleton D, Woollatt E, Mitchelhill KI, "et al." |title=AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 452–6 |year= 1997 |pmid= 9224708 |doi=
*cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=
*cite journal | author=Reinton N, Haugen TB, Orstavik S, "et al." |title=The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. |journal=Genomics |volume=49 |issue= 2 |pages= 290–7 |year= 1998 |pmid= 9598317 |doi= 10.1006/geno.1998.5240
*cite journal | author=Zidovetzki R, Wang JL, Chen P, "et al." |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825–33 |year= 1998 |pmid= 9671211 |doi=
*cite journal | author=Mayne M, Bratanich AC, Chen P, "et al." |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=
*cite journal | author=Cheung PC, Salt IP, Davies SP, "et al." |title=Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. |journal=Biochem. J. |volume=346 Pt 3 |issue= |pages= 659–69 |year= 2000 |pmid= 10698692 |doi=
*cite journal | author=Hamilton SR, Stapleton D, O'Donnell JB, "et al." |title=An activating mutation in the gamma1 subunit of the AMP-activated protein kinase. |journal=FEBS Lett. |volume=500 |issue= 3 |pages= 163–8 |year= 2001 |pmid= 11445078 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Minokoshi Y, Alquier T, Furukawa N, "et al." |title=AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. |journal=Nature |volume=428 |issue= 6982 |pages= 569–74 |year= 2004 |pmid= 15058305 |doi= 10.1038/nature02440

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