Proline oxidase

Proline oxidase

Proline dehydrogenase (oxidase) 1, also known as PRODH, is a human gene.cite web | title = Entrez Gene: PRODH proline dehydrogenase (oxidase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5625| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a mitochondrial proline dehydrogenase which catalyzes the first step in proline catabolism. Deletion of this gene has been associated with type I hyperprolinemia. The gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes DiGeorge syndrome and CATCH22 syndrome.cite web | title = Entrez Gene: PRODH proline dehydrogenase (oxidase) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5625| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Polyak K, Xia Y, Zweier JL, "et al." |title=A model for p53-induced apoptosis. |journal=Nature |volume=389 |issue= 6648 |pages= 300-5 |year= 1997 |pmid= 9305847 |doi= 10.1038/38525
*cite journal | author=Campbell HD, Webb GC, Young IG |title=A human homologue of the Drosophila melanogaster sluggish-A (proline oxidase) gene maps to 22q11.2, and is a candidate gene for type-I hyperprolinaemia. |journal=Hum. Genet. |volume=101 |issue= 1 |pages= 69-74 |year= 1997 |pmid= 9385373 |doi=
*cite journal | author=Gogos JA, Santha M, Takacs Z, "et al." |title=The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. |journal=Nat. Genet. |volume=21 |issue= 4 |pages= 434-9 |year= 1999 |pmid= 10192398 |doi= 10.1038/7777
*cite journal | author=Donald SP, Sun XY, Hu CA, "et al." |title=Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. |journal=Cancer Res. |volume=61 |issue= 5 |pages= 1810-5 |year= 2001 |pmid= 11280728 |doi=
*cite journal | author=Liu H, Heath SC, Sobin C, "et al." |title=Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 6 |pages= 3717-22 |year= 2002 |pmid= 11891283 |doi= 10.1073/pnas.042700699
*cite journal | author=Jacquet H, Raux G, Thibaut F, "et al." |title=PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. |journal=Hum. Mol. Genet. |volume=11 |issue= 19 |pages= 2243-9 |year= 2003 |pmid= 12217952 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Maxwell SA, Rivera A |title=Proline oxidase induces apoptosis in tumor cells, and its expression is frequently absent or reduced in renal carcinomas. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9784-9 |year= 2003 |pmid= 12514185 |doi= 10.1074/jbc.M210012200
*cite journal | author=Jacquet H, Berthelot J, Bonnemains C, "et al." |title=The severe form of type I hyperprolinaemia results from homozygous inactivation of the PRODH gene. |journal=J. Med. Genet. |volume=40 |issue= 1 |pages= e7 |year= 2003 |pmid= 12525555 |doi=
*cite journal | author=Williams HJ, Williams N, Spurlock G, "et al." |title=Detailed analysis of PRODH and PsPRODH reveals no association with schizophrenia. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=120 |issue= 1 |pages= 42-6 |year= 2004 |pmid= 12815738 |doi= 10.1002/ajmg.b.20049
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Li T, Ma X, Sham PC, "et al." |title=Evidence for association between novel polymorphisms in the PRODH gene and schizophrenia in a Chinese population. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=129 |issue= 1 |pages= 13-5 |year= 2005 |pmid= 15274030 |doi= 10.1002/ajmg.b.30049
*cite journal | author=Zhang M, White TA, Schuermann JP, "et al." |title=Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors. |journal=Biochemistry |volume=43 |issue= 39 |pages= 12539-48 |year= 2004 |pmid= 15449943 |doi= 10.1021/bi048737e
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jacquet H, Demily C, Houy E, "et al." |title=Hyperprolinemia is a risk factor for schizoaffective disorder. |journal=Mol. Psychiatry |volume=10 |issue= 5 |pages= 479-85 |year= 2005 |pmid= 15494707 |doi= 10.1038/sj.mp.4001597
*cite journal | author=Bender HU, Almashanu S, Steel G, "et al." |title=Functional consequences of PRODH missense mutations. |journal=Am. J. Hum. Genet. |volume=76 |issue= 3 |pages= 409-20 |year= 2005 |pmid= 15662599 |doi= 10.1086/428142
*cite journal | author=Rivera A, Maxwell SA |title=The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29346-54 |year= 2005 |pmid= 15914462 |doi= 10.1074/jbc.M504852200
*cite journal | author=Pandhare J, Cooper SK, Phang JM |title=Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms. |journal=J. Biol. Chem. |volume=281 |issue= 4 |pages= 2044-52 |year= 2006 |pmid= 16303758 |doi= 10.1074/jbc.M507867200
*cite journal | author=Liu Y, Borchert GL, Surazynski A, "et al." |title=Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. |journal=Oncogene |volume=25 |issue= 41 |pages= 5640-7 |year= 2006 |pmid= 16619034 |doi= 10.1038/sj.onc.1209564
*cite journal | author=Li D, He L |title=Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis. |journal=Eur. J. Hum. Genet. |volume=14 |issue= 10 |pages= 1130-5 |year= 2006 |pmid= 16791139 |doi= 10.1038/sj.ejhg.5201680

External links

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