Ornithine aminotransferase

Ornithine aminotransferase
ornithine aminotransferase
EC number
CAS number 9030-42-6
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
ornithine aminotransferase (gyrate atrophy)
Symbol OAT
Entrez 4942
HUGO 8091
OMIM 258870
RefSeq NM_000274
UniProt P04181
Other data
EC number
Locus Chr. 10 q26

Ornithine aminotransferase is an enzyme involved in the ultimate formation of proline from ornithine. Ornithine aminotransferase forms the initial intermediate in this process. It catalyzes the reverse reaction as well, and is therefore essential in creating ornithine from the starting substrate proline. Glutamate acts as the amine donor for ornithine aminotransferase, forming α-ketoglutarate. In the reverse direction, α-ketoglutarate accepts the amine group, forming glutamate and leading to the ultimate conversion of proline to ornithine.

Ornithine aminotransferase catalyzes the following reaction:

  • L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid

See also

External links

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