Ornithine aminotransferase

Ornithine aminotransferase
ornithine aminotransferase
Identifiers
EC number 2.6.1.13
CAS number 9030-42-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
ornithine aminotransferase (gyrate atrophy)
Identifiers
Symbol OAT
Entrez 4942
HUGO 8091
OMIM 258870
RefSeq NM_000274
UniProt P04181
Other data
EC number 2.6.1.13
Locus Chr. 10 q26

Ornithine aminotransferase is an enzyme involved in the ultimate formation of proline from ornithine. Ornithine aminotransferase forms the initial intermediate in this process. It catalyzes the reverse reaction as well, and is therefore essential in creating ornithine from the starting substrate proline. Glutamate acts as the amine donor for ornithine aminotransferase, forming α-ketoglutarate. In the reverse direction, α-ketoglutarate accepts the amine group, forming glutamate and leading to the ultimate conversion of proline to ornithine.

Ornithine aminotransferase catalyzes the following reaction:

  • L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid

See also

External links

v · d · eTransferase: nitrogenous groups (EC 2.6)
2.6.1: Transaminases
2.6.3: Oximinotransferases
2.6.99: Other
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
v · d · eMetabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS)
K→acetyl-CoA
(see below)
G
G→pyruvate
→citrate
G→glutamate→
α-ketoglutarate
Ornithine aminotransferase · Ornithine decarboxylase · Agmatinase
→alpha-ketoglutarate→TCA
Other
→succinyl-CoA→TCA
G→fumarate
asparagine→aspartate→

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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Look at other dictionaries:

  • ornithine aminotransferase — or·ni·thine ami·no·trans·fer·ase (orґnĭ thēn ə me″no transґfər ās) an enzyme of the transferase class that catalyzes the conversion of ornithine to Δ1 pyrroline 5 carboxylate via transfer of the ornithine amino …   Medical dictionary

  • Ornithine decarboxylase — Identifiers EC number 4.1.1.17 CAS number 9024 60 6 …   Wikipedia

  • Ornithine decarboxylase antizyme — is a ornithine decarboxylase inhibitor. It was first characterized in 1981.[1] The genes include OAZ1, OAZ2, and OAZ3. References ^ …   Wikipedia

  • Ornithine(lysine) transaminase — Identifiers EC number 2.6.1.68 CAS number 105542 39 0 …   Wikipedia

  • ornithine — 2,5 Diaminovaleric acid; the l isomer is the amino acid formed when l arginine is hydrolyzed by arginase; not a constituent of proteins, but an important intermediate in the urea cycle; elevated levels seen in certain defects of the urea cycle. o …   Medical dictionary

  • OATL — ornithine aminotransferase like …   Medical dictionary

  • OATL — • ornithine aminotransferase like …   Dictionary of medical acronyms & abbreviations

  • Aspartate transaminase — Aspartate aminotransferase from Escherichia coli bound with cofactor pyridoxal 5 phosphate.[1] Identifiers …   Wikipedia

  • Amino acid — This article is about the class of chemicals. For the structures and properties of the standard proteinogenic amino acids, see Proteinogenic amino acid. The generic structure of an alpha amino acid in its unionized form …   Wikipedia

  • Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… …   Wikipedia

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