Betaine-homocysteine S-methyltransferase

Betaine-homocysteine S-methyltransferase

In enzymology, a betaine-homocysteine S-methyltransferase (EC number|2.1.1.5) is an enzyme that catalyzes the chemical reaction

:trimethylammonioacetate + L-homocysteine ightleftharpoons dimethylglycine + L-methionine

Thus, the two substrates of this enzyme are trimethylammonioacetate and L-homocysteine, whereas its two products are dimethylglycine and L-methionine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is trimethylammonioacetate:L-homocysteine S-methyltransferase. Other names in common use include betaine-homocysteine methyltransferase, and betaine-homocysteine transmethylase. This enzyme participates in the metabolism of glycine, serine, threonine and also methionine.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1LT7, PDB link|1LT8, and PDB link|1UMY.

References

*

External links

::"The CAS registry number for this enzyme class is CAS registry|9029-78-1."

Gene Ontology (GO) codes


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