4-Hydroxyphenylpyruvate dioxygenase
- 4-Hydroxyphenylpyruvate dioxygenase
Protein
Name=4-hydroxyphenylpyruvate dioxygenase
Symbol=HPD
AltSymbols=PPD;
HGNCid=5147
Chromosome=12
Arm=q
Band=24-qter
LocusSupplementaryData=
ECnumber=1.13.11.27
OMIM=609695
EntrezGene=3242
RefSeq=NM_002150
UniProt=P32754
4-Hydroxyphenylpyruvate dioxygenase HPD is a Cu-containing enzyme, that catalyzes the third reaction in the catabolism of phenylalanine and tyrosine - the conversion of 4-hydroxyphenylpyruvate to homogentisate.
Function
The HPD reaction occurs through a NIH shift and involves the oxidative decarboxylation of an α-oxo acid as well as aromatic ring hydroxylation. The NIH-shift, which has been demonstrated through isotope-labeling studies, involves migration of an alkyl group to form a more stable carbocation. The shift, accounts for the observation that C3 is bonded to C4 in 4-hydroxyphenylpyruvate but to C5 in homogentisate.
ee also
* 4-Alpha-hydroxyphenylpyruvate hydroxylase deficiency
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