Cysteine dioxygenase

Cysteine dioxygenase
cysteine dioxygenase, type I
Identifiers
Symbol CDO1
Entrez 1036
HUGO 1795
OMIM 603943
RefSeq NM_001801
UniProt Q16878
Other data
EC number 1.13.11.20
Locus Chr. 5 q23.2

Cysteine dioxygenase (CDO, CAS number: 37256-59-0)) is a mammalian non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.

CDO reaction scheme showing cysteine sulfinic acid formation from cysteine by dioxygen incorporation

Cysteine sulfinic acid lies at a branch-point in cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate. The cysteine sulfinic acid-dependent pathway of taurine metabolism follows the synthesis of hypotaurine (2-aminoethane sulfinate), which is subsequently oxidized to taurine. Also, cysteine sulfinate can undergo transamination to form β-sulfinylpyruvate, decomposing to form pyruvate and sulfite.

References

  • Sakakibara S, Yamaguchi K, Hosokawa Y, Kohashi N, Ueda I (February 1976). "Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase)". Biochim. Biophys. Acta 422 (2): 273–9. PMID 2307. 
v · d · eMetabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS)
K→acetyl-CoA
(see below)
G
G→pyruvate
→citrate
G→glutamate→
α-ketoglutarate
→alpha-ketoglutarate→TCA
Other
→succinyl-CoA→TCA
G→fumarate
asparagine→aspartate→

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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