PYCR1

Pyrroline-5-carboxylate reductase 1, also known as PYCR1, is a human gene.cite web | title = Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5831| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.cite web | title = Entrez Gene: PYCR1 pyrroline-5-carboxylate reductase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5831| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Herzfeld A, Legg MA, Greengard O |title=Human colon tumors: enzymic and histological characteristics. |journal=Cancer |volume=42 |issue= 3 |pages= 1280–3 |year= 1978 |pmid= 212173 |doi=
*cite journal | author=Dougherty KM, Brandriss MC, Valle D |title=Cloning human pyrroline-5-carboxylate reductase cDNA by complementation in Saccharomyces cerevisiae. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 871–5 |year= 1992 |pmid= 1730675 |doi=
*cite journal | author=Merrill MJ, Yeh GC, Phang JM |title=Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH. |journal=J. Biol. Chem. |volume=264 |issue= 16 |pages= 9352–8 |year= 1989 |pmid= 2722838 |doi=
*cite journal | author=Yeh GC, Roth EF, Phang JM, "et al." |title=The effect of pyrroline-5-carboxylic acid on nucleotide metabolism in erythrocytes from normal and glucose-6-phosphate dehydrogenase-deficient subjects. |journal=J. Biol. Chem. |volume=259 |issue= 9 |pages= 5454–8 |year= 1984 |pmid= 6201483 |doi=
*cite journal | author=Herzfeld A, Greengard O |title=Enzyme activities in human fetal and neoplastic tissues. |journal=Cancer |volume=46 |issue= 9 |pages= 2047–54 |year= 1981 |pmid= 6253048 |doi=
*cite journal | author=Yeh GC, Harris SC, Phang JM |title=Pyrroline-5-carboxylate reductase in human erythrocytes. |journal=J. Clin. Invest. |volume=67 |issue= 4 |pages= 1042–6 |year= 1981 |pmid= 6894153 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Basch JJ, Wickham ED, Farrell HM |title=Pyrroline-5-carboxylate reductase in lactating bovine mammary glands. |journal=J. Dairy Sci. |volume=79 |issue= 8 |pages= 1361–8 |year= 1997 |pmid= 8880459 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Meng Z, Lou Z, Liu Z, "et al." |title=Crystal structure of human pyrroline-5-carboxylate reductase. |journal=J. Mol. Biol. |volume=359 |issue= 5 |pages= 1364–77 |year= 2006 |pmid= 16730026 |doi= 10.1016/j.jmb.2006.04.053

PBB_Controls
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require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes