Cystathionine gamma-lyase

Cystathionine gamma-lyase
cystathionine gamma-lyase
Cysteine Biosynthesis.png
Cysteine metabolism. Cystathionase catalyzes the lower reaction.
Identifiers
EC number 4.4.1.1
CAS number 9012-96-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Cystathionine gamma-lyase (or cystathionase) is an enzyme which breaks down cystathionine into cysteine and α-ketobutyrate. Pyridoxal phosphate is a prosthetic group of this enzyme.

Cystathionine gamma-lyase also catalyses the following elimination reactions:

In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide.[1]

Contents

Examples

The following cystathionine gamma-lyase is expressed in humans:

cystathionase (cystathionine gamma-lyase)
Identifiers
Symbol CTH
Entrez 1491
HUGO 2501
OMIM 607657
RefSeq NM_001902
UniProt P32929
Other data
EC number 4.4.1.1
Locus Chr. 1 p31.1

Pathology

An deficiency is associated with cystathioninuria.

See also

External links

References

  1. ^ Wang R (March 2010). "Toxic Gas, Lifesaver". Scientific American: 52. http://www.scientificamerican.com/article.cfm?id=toxic-gas-lifesaver. 
v · d · eMetabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS)
K→acetyl-CoA
(see below)
G
G→pyruvate
→citrate
G→glutamate→
α-ketoglutarate
→alpha-ketoglutarate→TCA
Other
→succinyl-CoA→TCA
G→fumarate
asparagine→aspartate→

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

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