Guanidinoacetate N-methyltransferase

Guanidinoacetate N-methyltransferase

In enzymology, a guanidinoacetate N-methyltransferase (EC number|2.1.1.2) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + guanidinoacetate ightleftharpoons S-adenosyl-L-homocysteine + creatine

Thus, the two substrates of this enzyme are S-adenosyl methionine and guanidinoacetate, whereas its two products are S-adenosylhomocysteine and creatine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase. Other names in common use include GA methylpherase, guanidinoacetate methyltransferase, guanidinoacetate transmethylase, methionine-guanidinoacetic transmethylase, and guanidoacetate methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and arginine and proline metabolism.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1KHH, PDB link|1P1B, PDB link|1P1C, PDB link|1XCJ, PDB link|1XCL, PDB link|1ZX0, and PDB link|2BLN.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9029-75-8."

Gene Ontology (GO) codes


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