Guanidinoacetate N-methyltransferase
- Guanidinoacetate N-methyltransferase
In enzymology, a guanidinoacetate N-methyltransferase (EC number|2.1.1.2) is an enzyme that catalyzes the chemical reaction
:S-adenosyl-L-methionine + guanidinoacetate S-adenosyl-L-homocysteine + creatine
Thus, the two substrates of this enzyme are S-adenosyl methionine and guanidinoacetate, whereas its two products are S-adenosylhomocysteine and creatine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase. Other names in common use include GA methylpherase, guanidinoacetate methyltransferase, guanidinoacetate transmethylase, methionine-guanidinoacetic transmethylase, and guanidoacetate methyltransferase. This enzyme participates in glycine, serine and threonine metabolism and arginine and proline metabolism.
tructural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1KHH, PDB link|1P1B, PDB link|1P1C, PDB link|1XCJ, PDB link|1XCL, PDB link|1ZX0, and PDB link|2BLN.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9029-75-8."
Gene Ontology (GO) codes
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Look at other dictionaries:
guanidinoacetate N-methyltransferase — The enzyme catalyzing the transfer of a methyl group from S adenosyl l methionine (“active methionine”) to guanidinoacetate (glycocyamine), forming creatine and S adenosyl l homocysteine. * * * gua·ni·di·no·ac·e·tate N meth·yl·trans·fer·ase… … Medical dictionary
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