Tryptophan 2,3-dioxygenase

In enzymology, a tryptophan 2,3-dioxygenase (EC number|1.13.11.11) is an enzyme that catalyzes the chemical reaction

:L-tryptophan + O₂ $ightleftharpoons$ N-formyl-L-kynurenine

Thus, the two substrates of this enzyme are L-tryptophan and O₂, whereas its product is N-formyl-L-kynurenine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing). Other names in common use include tryptophan pyrrolase (ambiguous), tryptophanase, tryptophan oxygenase, tryptamine 2,3-dioxygenase, tryptophan peroxidase, indoleamine 2,3-dioxygenase (ambiguous), indolamine 2,3-dioxygenase (ambiguous), L-tryptophan pyrrolase, TDO, and L-tryptophan 2,3-dioxygenase. This enzyme participates in tryptophan metabolism. It employs one cofactor, heme.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1YW0 and PDB link|2NOX.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9014-51-1."

Gene Ontology (GO) codes