Tryptophan 2'-dioxygenase

In enzymology, a tryptophan 2'-dioxygenase (EC number|1.13.99.3) is an enzyme that catalyzes the chemical reaction

:L-tryptophan + O₂ $ightleftharpoons$ (indol-3-yl)glycolaldehyde + CO₂ + NH₃

Thus, the two substrates of this enzyme are L-tryptophan and O₂, whereas its 3 products are (indol-3-yl)glycolaldehyde, CO₂, and NH₃.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving). Other names in common use include indole-3-alkane alpha-hydroxylase, tryptophan side-chain alpha,beta-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan alpha-hydroxylase, tryptophan side chain oxidase type I, TSO I, TSO II, and tryptophan side chain oxidase. This enzyme participates in tryptophan metabolism. It employs one cofactor, heme.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|64295-81-4."

Gene Ontology (GO) codes