Wee1-like protein kinase

WEE1 homolog ("S. pombe"), also known as WEE1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.cite web | title = Entrez Gene: WEE1 WEE1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7465| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193–205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789
*cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013
*cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue= |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11
*cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279
*cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=
*cite journal | author=Li L, Li HS, Pauza CD, "et al." |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370
*cite journal | author=Igarashi M, Nagata A, Jinno S, "et al." |title=Wee1(+)-like gene in human cells. |journal=Nature |volume=353 |issue= 6339 |pages= 80–3 |year= 1991 |pmid= 1840647 |doi= 10.1038/353080a0
*cite journal | author=Baldin V, Ducommun B |title=Subcellular localisation of human wee1 kinase is regulated during the cell cycle. |journal=J. Cell. Sci. |volume=108 ( Pt 6) |issue= |pages= 2425–32 |year= 1995 |pmid= 7673359 |doi=
*cite journal | author=Watanabe N, Broome M, Hunter T |title=Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. |journal=EMBO J. |volume=14 |issue= 9 |pages= 1878–91 |year= 1995 |pmid= 7743995 |doi=
*cite journal | author=McGowan CH, Russell P |title=Cell cycle regulation of human WEE1. |journal=EMBO J. |volume=14 |issue= 10 |pages= 2166–75 |year= 1995 |pmid= 7774574 |doi=
*cite journal | author=Kharbanda S, Yuan ZM, Taneja N, "et al." |title=p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C. |journal=Oncogene |volume=9 |issue= 10 |pages= 3005–11 |year= 1994 |pmid= 8084605 |doi=
*cite journal | author=Heald R, McLoughlin M, McKeon F |title=Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. |journal=Cell |volume=74 |issue= 3 |pages= 463–74 |year= 1993 |pmid= 8348613 |doi=
*cite journal | author=McGowan CH, Russell P |title=Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15. |journal=EMBO J. |volume=12 |issue= 1 |pages= 75–85 |year= 1993 |pmid= 8428596 |doi=
*cite journal | author=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. |journal=Genomics |volume=15 |issue= 1 |pages= 194–6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032
*cite journal | author=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=
*cite journal | author=Zhou BB, Li H, Yuan J, Kirschner MW |title=Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6785–90 |year= 1998 |pmid= 9618490 |doi=
*cite journal | author=Taylor WR, DePrimo SE, Agarwal A, "et al." |title=Mechanisms of G2 arrest in response to overexpression of p53. |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3607–22 |year= 1999 |pmid= 10564259 |doi=
*cite journal | author=Wang Y, Jacobs C, Hook KE, "et al." |title=Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population. |journal=Cell Growth Differ. |volume=11 |issue= 4 |pages= 211–9 |year= 2000 |pmid= 10775038 |doi=
*cite journal | author=Cichutek A, Brueckmann T, Seipel B, "et al." |title=Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). |journal=Cytogenet. Cell Genet. |volume=93 |issue= 3-4 |pages= 277–83 |year= 2001 |pmid= 11528126 |doi=
*cite journal | author=Elder RT, Yu M, Chen M, "et al." |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359–70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007

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