PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1, also known as PKMYT1, is a human gene.cite web | title = Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9088| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9088| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Liu F, Stanton JJ, Wu Z, Piwnica-Worms H |title=The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 571–83 |year= 1997 |pmid= 9001210 |doi=
*cite journal | author=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=
*cite journal | author=Shen M, Stukenberg PT, Kirschner MW, Lu KP |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 706–20 |year= 1998 |pmid= 9499405 |doi=
*cite journal | author=Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H |title=Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5113–23 |year= 1999 |pmid= 10373560 |doi=
*cite journal | author=Wells NJ, Watanabe N, Tokusumi T, "et al." |title=The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. |journal=J. Cell. Sci. |volume=112 ( Pt 19) |issue= |pages= 3361–71 |year= 1999 |pmid= 10504341 |doi=
*cite journal | author=Pathan N, Aime-Sempe C, Kitada S, "et al." |title=Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. |journal=Neoplasia |volume=3 |issue= 1 |pages= 70–9 |year= 2001 |pmid= 11326318 |doi= 10.1038/sj/neo/7900131
*cite journal | author=Okumura E, Fukuhara T, Yoshida H, "et al." |title=Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 111–6 |year= 2002 |pmid= 11802161 |doi= 10.1038/ncb741
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Passer BJ, Nancy-Portebois V, Amzallag N, "et al." |title=The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2284–9 |year= 2003 |pmid= 12606722 |doi= 10.1073/pnas.0530298100
*cite journal | author=Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E |title=Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25277–80 |year= 2003 |pmid= 12738781 |doi= 10.1074/jbc.C300126200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dai X, Yamasaki K, Yang L, "et al." |title=Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation. |journal=J. Invest. Dermatol. |volume=122 |issue= 6 |pages= 1356–64 |year= 2004 |pmid= 15175024 |doi= 10.1111/j.0022-202X.2004.22522.x
*cite journal | author=Martin J, Han C, Gordon LA, "et al." |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187
*cite journal | author=Bryan BA, Dyson OF, Akula SM |title=Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency. |journal=J. Gen. Virol. |volume=87 |issue= Pt 3 |pages= 519–29 |year= 2006 |pmid= 16476973 |doi= 10.1099/vir.0.81603-0
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Wissing J, Jänsch L, Nimtz M, "et al." |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200

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