Protein kinase domain

Protein kinases are a group of enzymes that possess a catalytic subunit which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. The enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine specific and tyrosine specificcite journal |author=Hunter T, Hanks SK, Quinn AM |title=The protein kinase family: conserved features and deduced phylogeny of the catalytic domains |journal=Science |volume=241 |issue=4861 |pages=42–51 |year=1988 |pmid=3291115 |doi=10.1126/science.3291115] .

Protein kinase function has been evolutionarily conserved from "Escherichia coli" to "Homo sapiens". Protein kinases play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiationcite journal |author=Hunter T, Plowman GD, Manning G, Sudarsanam S |title=Evolution of protein kinase signaling from yeast to man |journal=Trends Biochem. Sci. |volume=27 |issue=10 |pages=514–520 |year=2002 |pmid=12368087 |doi=10.1016/S0968-0004(02)02179-5] . Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins.

Human proteins containing this domain

AAK1; ACVR1; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; ADRBK1;
ADRBK2; AKT1; AKT2; AKT3; ALS2CR2; ALS2CR7; AMHR2; ANKK1;
ARAF; AURKA; AURKB; AURKC; BMP2K; BMPR1A; BMPR1B; BMPR2;
BRAF; BRSK1; BRSK2; BUB1; C14orf20; CAMK1; CAMK1D; CAMK1G;
CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMK4; CAMKK1; CAMKK2; CAMKV;
CASK; CCRK; CDC2; CDC2L1; CDC2L2; CDC2L5; CDC2L6; CDC42BPA;
CDC42BPB; CDC42BPG; CDC7; CDK10; CDK2; CDK3; CDK4; CDK5;
CDK6; CDK7; CDK8; CDK9; CDKL1; CDKL2; CDKL3; CDKL4;
CDKL5; CHEK1; CHEK2; CHUK; CIT; CLK1; CLK2; CLK3;
CLK4; CRKRS; CSNK1A1; CSNK1A1L; CSNK1D; CSNK1E; CSNK1G1; CSNK1G2;
CSNK1G3; CSNK2A1; CSNK2A2; DAPK1; DAPK2; DAPK3; DCAMKL1; DCLK1;
DCLK2; DCLK3; DMPK; DYRK1A; DYRK1B; DYRK2; DYRK3; DYRK4;
EIF2AK1; EIF2AK3; EIF2AK4; ERN1; ERN2; GAK; GRK1; GRK4;
GRK5; GRK6; GRK7; GSK3A; GSK3B; GUCY2C; GUCY2D; GUCY2F;
HIPK1; HIPK2; HIPK3; HIPK4; HUNK; ICK; IKBKB; IKBKE;
IRAK1; IRAK2; IRAK3; IRAK4; KALRN; KIAA0999; KSR2; LATS1;
LATS2; LIMK1; LIMK2; LOC402468; LOC407835; LRRK1; LRRK2; MAK;
MAP2K1; MAP2K2; MAP2K3; MAP2K4; MAP2K5; MAP2K6; MAP2K7; MAP3K1;
MAP3K10; MAP3K11; MAP3K12; MAP3K13; MAP3K14; MAP3K15; MAP3K2; MAP3K3;
MAP3K4; MAP3K5; MAP3K6; MAP3K7; MAP3K8; MAP3K9; MAP4K1; MAP4K2;
MAP4K3; MAP4K4; MAP4K5; MAPK1; MAPK10; MAPK12; MAPK13; MAPK14;
MAPK15; MAPK3; MAPK4; MAPK6; MAPK7; MAPK8; MAPK9; MAPKAPK2;
MAPKAPK3; MAPKAPK5; MARK1; MARK2; MARK3; MARK4; MAST1; MAST2;
MAST3; MAST4; MASTL; MELK; MELKv2; MELKv3; MINK; MINK1;
MKNK1; MKNK2; MLK4; MLKL; MOS; MST094; MST4; MYLK;
MYLK2; MYLK3; MYO3A; MYO3B; NEK1; NEK10; NEK11; NEK2;
NEK3; NEK4; NEK5; NEK6; NEK7; NEK8; NEK9; NIM1;
NLK; NPR2; NRBP1; NRK; NUAK1; NUAK2; OBSCN; OXSR1;
PAK1; PAK2; PAK3; PAK4; PAK6; PAK7; PASK; PBK;
PCTK1; PCTK2; PCTK3; PDIK1L; PDPK1; PDPK2; PFTK1; PHKG1;
PHKG2; PIK3R4; PIM1; PIM2; PIM3; PINK1; PKMYT1; PKN1;
PKN2; PKN3; PLK1; PLK2; PLK3; PLK5; PNCK; PRKAA1;
PRKAA2; PRKACA; PRKACB; PRKACG; PRKCA; PRKCB1; PRKCD; PRKCE;
PRKCG; PRKCH; PRKCI; PRKCN; PRKCQ; PRKCZ; PRKD1; PRKD2;
PRKD3; PRKG1; PRKG2; PRKX; PRKY; PRPF4B; PSKH1; PSKH2;
QSK; RAF1; RAGE; RIP3; RIPK1; RIPK2; RIPK3; RIPK4;
RIPK5; RK; RNASEL; ROCK1; ROCK2; RPS6KA1; RPS6KA2; RPS6KA3;
RPS6KA4; RPS6KA5; RPS6KA6; RPS6KB1; RPS6KB2; RPS6KC1; RPS6KL1; SBK1;
SCYL2; SCYL3; SGK; SGK069; SGK071; SGK085; SGK110; SGK196;
SGK2; SGK269; SGK3; SGK494; SGKL; SLK; SNF1LK; SNF1LK2;
SNRK; SPEG; SRPK1; SRPK2; SRPK3; STK10; STK11; STK16;
STK17A; STK17B; STK24; STK25; STK3; STK31; STK32A; STK32B;
STK32C; STK33; STK35; STK36; STK38; STK38L; STK39; STK4;
STK40; STRAD; TAK1; TAOK1; TAOK2; TAOK3; TBCK; TBK1;
TESK1; TESK2; TGFBR1; TGFBR2; TLK1; TLK2; TNIK; TRIB1;
TRIB2; TRIB3; TRIO; TSSK1; TSSK1B; TSSK2; TSSK3; TSSK4;
TSSK6; TTBK1; TTBK2; TTK; TTN; UHMK1; ULK1; ULK2;
ULK3; ULK4; VRK1; VRK2; WEE1; WEE1B; WNK1; WNK2;
WNK3; WNK4; YSK4; dik;

References

Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

Protein kinase — A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). This class of protein may further be separated into subsets as in the case of protein kinase C PKC alpha, PKC beta,… … Wikipedia
Protein kinase C — ( PKC , EC number|2.7.11.13) is a family of protein kinases consisting of 10 isozymes.cite journal | author = Mellor H, Parker PJ | title = The extended protein kinase C superfamily | journal = Biochem. J. | volume = 332 ( Pt 2) | issue = | pages … Wikipedia
Protein kinase R — (Eukaryotic translation initiation factor 2 alpha kinase 2) is a protein protecting against viral infections. EIF2AK2 is its human gene.cite web | title = Entrez Gene: EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2| url =… … Wikipedia
Protein kinase N1 — Protein kinase N1, also known as PKN1, is a human gene.cite web | title = Entrez Gene: PKN1 protein kinase N1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5585| accessdate = ] PBB Summary section title … Wikipedia
Protein kinase Mζ — (also called PKMζ or PKMzeta) is the independent catalytic domain of protein kinase Cζ and, lacking an autoinhibitory regulatory domain of the full length PKCζ, is constitutively active. This constitutive or autonomous activity allows the kinase… … Wikipedia
Protein kinase D1 — Protein kinase D1, also known as PRKD1, is a human gene.cite web | title = Entrez Gene: PRKD1 protein kinase D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5587| accessdate = ] PBB Summary section title … Wikipedia
Protein kinase A — In cell biology, Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP dependent protein kinase (EC 2.7.11.11). Protein kinase A has several functions… … Wikipedia
CGMP-dependent protein kinase — protein Name= protein kinase, cGMP dependent, type I caption= width= HGNCid=9414 Symbol=PRKG1 AltSymbols=PRKGR1B, PRKG1B EntrezGene=5592 OMIM=176894 RefSeq=NM 006258 UniProt=P14619 PDB= ECnumber= Chromosome=10 Arm=q Band=11.2… … Wikipedia
protein kinase N — (= PKN; PRK1) Serine/threonine kinase (100 kD) probably regulated by rho dependent phosphorylation. Kinase activity resides in the C terminal region (which has high homology with the catalytic domain of PKC). The N terminal region, through which… … Dictionary of molecular biology
protein kinase C — Family of protein serine/threonine kinases activated by phospholipids that play an important part in intracellular signalling. The classical PKCs ( a, b1, b2, g) are also calcium dependent and can be activated by diacyl glycerol, one of the… … Dictionary of molecular biology

Academic Dictionaries and Encyclopedias

Protein kinase domain

Look at other dictionaries:

Share the article and excerpts

Academic Dictionaries and Encyclopedias

Wikipedia

Protein kinase domain

Look at other dictionaries:

Share the article and excerpts

Direct link