Dual-specificity kinase

Dual-specificity kinase: Dual-specificity kinase

Identifiers

EC number 2.7.12.1

CAS number 134549-83-0

Databases

IntEnz IntEnz view

BRENDA BRENDA entry

ExPASy NiceZyme view

KEGG KEGG entry

MetaCyc metabolic pathway

PRIAM profile

PDB structures RCSB PDB PDBe PDBsum

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PMC articles

PubMed articles

In biochemistry, a dual-specificity kinase (EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase.

MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:

ADK1

Arabidopsis dual specificity kinase 1

CLK1, CLK2, CLK3, CLK4

DSTYK

DYR1A, DYR1B, DYRK2, DYRK3, DYRK4

Mps1p

TESK1, TESK2

TTK

The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).

References

Dhanasekaran N, Premkumar Reddy E (1998). "Signaling by dual specificity kinases". Oncogene 17 (11 Reviews): 1447–1455. doi:10.1038/sj.onc.1202251. PMID 9779990.

Ali N, Halfter U, Chua NH (1994). "Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine". J. Biol. Chem. 269 (50): 31626–9. PMID 7527390.

Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. PMC 398258. PMID 7737118. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=398258.

Menegay HJ, Myers MP, Moeslein FM, Landreth GE (Pt 18). "Biochemical characterization and localization of the dual specificity kinase CLK1". J. Cell. Sci. 113: 3241–53. PMID 10954422.

Cleghon V; Sibbet, G; Kinstrie, R; Cleghon, T; Rylatt, M; Morrison, DK; Cleghon, V (2003). "dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila". Biochem. J. 374 (Pt 2): 381–91. doi:10.1042/BJ20030500. PMC 1223608. PMID 12786602. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223608.

v · d · eTransferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor

Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD⁺ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor

Phosphoglycerate · Aspartate

2.7.3: N acceptor

Creatine

2.7.4: PO₄ acceptor

Phosphomevalonate · Adenylate · Nucleoside-diphosphate · Uridylate · Guanylate · Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)
Ribose-phosphate diphosphokinase · Thiamine diphosphokinase

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase

DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme
RNA-directed DNA polymerase: Reverse transcriptase (Telomerase)
DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase

RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase
PNPase

Phosphorolytic
3' to 5' exoribonuclease

RNase PH · PNPase

Uridylyltransferase

Glucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

Recombinase (Integrase) · Transposase

2.7.8: miscellaneous

Phosphatidyltransferases

CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase

Glycosyl-1-phosphotransferase

N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine

see tyrosine kinases

2.7.11: protein-serine/threonine

see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity

see serine/threonine-specific protein kinases

2.7.13: protein-histidine

Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

v · d · eKinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)

LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Protein kinase B (AKT1, AKT2, AKT3), Ataxia telangiectasia mutated, Mammalian target of rapamycin, EIF-2 kinases (PKR, HRI, EIF2AK3, EIF2AK4), Wee1 (WEE1)

Pyruvate dehydrogenase kinase (EC 2.7.11.2)

PDK1, PDK2, PDK3

Dephospho-(reductase kinase) kinase (EC 2.7.11.3)

AMP-activated protein kinase α (PRKAA1, PRKAA2) · β (PRKAB1, PRKAB2) · γ (PRKAG1, PRKAG2, PRKAG3)

(3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) (EC 2.7.11.4)

BCKDK, BCKDHA, BCKDHB

(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)

IDH2, IDH3A, IDH3B, IDH3G

(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)

STK4

Myosin-heavy-chain kinase (EC 2.7.11.7)

Aurora kinase (Aurora A kinase, Aurora B kinase)

Fas-activated serine/threonine kinase (EC 2.7.11.8)

FASTK, STK10

Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)

-

IκB kinase (EC 2.7.11.10)

CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP

cAMP-dependent protein kinase (EC 2.7.11.11)

Protein kinase A, PRKACG, PRKACB, PRKACA, PRKY

cGMP-dependent protein kinase (EC 2.7.11.12)

Protein kinase G, PRKG1

Protein kinase C (EC 2.7.11.13)

Protein kinase C, Protein kinase Cζ, PKC alpha, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Protein kinase N1, PKN2, PKN3,

Rhodopsin kinase (EC 2.7.11.14)

Rhodopsin kinase

Beta adrenergic receptor kinase (EC 2.7.11.15)

Beta adrenergic receptor kinase, Beta adrenergic receptor kinase-2

G-protein coupled receptor kinases (EC 2.7.11.16)

GRK4, GRK5, GRK6

Ca2+/calmodulin-dependent (EC 2.7.11.17)

BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1

Myosin light-chain kinase (EC 2.7.11.18)

MYLK, MYLK2, MYLK3, MYLK4

Phosphorylase kinase (EC 2.7.11.19)

PHKA1, PHKA2, PHKB, PHKG1, PHKG2

Elongation factor 2 kinase (EC 2.7.11.20)

EEF2K, STK19

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)

PLK1, PLK2, PLK3, PLK4

Cyclin-dependent kinase (EC 2.7.11.22)

CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1

(RNA-polymerase)-subunit kinase (EC 2.7.11.23)

RPS6KA5, RPS6KA4, P70S6 kinase, P70-S6 Kinase 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1

Mitogen-activated protein kinase (EC 2.7.11.24)

Extracellular signal-regulated (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogen-activated protein (MAPK11, MAPK13, MAPK14)

MAP3K (EC 2.7.11.25)

MAP kinase kinase kinases (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLKs (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14

Tau-protein kinase (EC 2.7.11.26)

TPK1, TTK, GSK-3

(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)

-

Tropomyosin kinase (EC 2.7.11.28)

-

Low-density-lipoprotein receptor kinase (EC 2.7.11.29)

-

Receptor protein serine/threonine kinase (EC 2.7.11.30)

Bone morphogenetic protein receptors (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K

MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

v · Intracellular signaling peptides and proteins

MAP
see MAP kinase pathway

Calcium
Intracellular calcium-sensing proteins • Calcineurin • Calcium-calmodulin-dependent protein kinase

G protein

Heterotrimeric

cAMP: Heterotrimeric G protein (Gs/Gi) • Adenylate cyclase • cAMP • 3',5'-cyclic-AMP phosphodiesterase • Protein kinase A

cGMP: Guanylate cyclase • cGMP • 3',5'-cyclic-GMP phosphodiesterase • Protein kinase G

Beta-gamma complex G_β (GNB1, GNB2, GNB3, GNB4, GNB5) • G_γ (GNGT1, GNGT2, GNG2, GNG3, GNG4, GNG5, GNG7, GNG8, GNG10, GNG11, GNG12, GNG13, BSCL2)
G protein-coupled receptor kinase • AMP-activated protein kinase

Monomeric

ARFs · Rabs · Ras (HRAS, KRAS, NRAS)

Cyclin
Cyclin-dependent kinase inhibitor protein • Cyclin-dependent kinase • Cyclin

Lipid
Phosphoinositide phospholipase C • Phospholipase c gamma

Other protein kinase

Serine/threonine: Casein kinase (1, 2) • eIF-2 kinase (EIF2AK3) • Glycogen synthase kinase (GSK1, GSK2, GSK-3, GSK3A, GSK3B) • IκB kinase (CHUK, IKK2, IKBKG) • Interleukin-1 receptor-associated kinase (IRAK1, IRAK2, IRAK3, IRAK4) • Lim kinase (LIMK1, LIMK2) • p21 activated kinases (PAK1, PAK2, PAK3, PAK4) • Rho-associated protein kinase (ROCK1, ROCK2) • Ribosomal s6 kinase (RPS6KA1)

Tyrosine: ZAP70 • Focal adhesion protein-tyrosine kinase (PTK2, PTK2B) • BTK
both: Dual-specificity kinase

Other phosphoprotein phosphatase

Serine/threonine: Protein phosphatase 2

Tyrosine: protein tyrosine phosphatase: Receptor-like protein tyrosine phosphatase • Sh2 domain-containing protein tyrosine phosphatase
both: Dual-specificity phosphatase

Apoptosis
see apoptosis signaling pathway

GTP-binding protein regulators
see GTP-binding protein regulators

Other
Activating transcription factor 6 • Signal transducing adaptor protein • I-kappa B protein • Mucin-4 • Olfactory marker protein • Phosphatidylethanolamine binding protein • EDARADD • PRKCSH

see also deficiencies of intracellular signaling peptides and proteins
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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