IRAK1

IRAK1

Interleukin-1 receptor-associated kinase 1, also known as IRAK1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: IRAK1 interleukin-1 receptor-associated kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3654| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Auron PE |title=The interleukin 1 receptor: ligand interactions and signal transduction. |journal=Cytokine Growth Factor Rev. |volume=9 |issue= 3-4 |pages= 221–37 |year= 1999 |pmid= 9918122 |doi=
*cite journal | author=Cao Z, Henzel WJ, Gao X |title=IRAK: a kinase associated with the interleukin-1 receptor. |journal=Science |volume=271 |issue= 5252 |pages= 1128–31 |year= 1996 |pmid= 8599092 |doi=
*cite journal | author=Cao Z, Xiong J, Takeuchi M, "et al." |title=TRAF6 is a signal transducer for interleukin-1. |journal=Nature |volume=383 |issue= 6599 |pages= 443–6 |year= 1996 |pmid= 8837778 |doi= 10.1038/383443a0
*cite journal | author=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. |journal=Genomics |volume=44 |issue= 1 |pages= 8–14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822
*cite journal | author=Huang J, Gao X, Li S, Cao Z |title=Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 24 |pages= 12829–32 |year= 1998 |pmid= 9371760 |doi=
*cite journal | author=Muzio M, Ni J, Feng P, Dixit VM |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. |journal=Science |volume=278 |issue= 5343 |pages= 1612–5 |year= 1997 |pmid= 9374458 |doi=
*cite journal | author=Muzio M, Natoli G, Saccani S, "et al." |title=The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 2097–101 |year= 1998 |pmid= 9625770 |doi=
*cite journal | author=Maschera B, Ray K, Burns K, Volpe F |title=Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB. |journal=Biochem. J. |volume=339 ( Pt 2) |issue= |pages= 227–31 |year= 1999 |pmid= 10191251 |doi=
*cite journal | author=Wesche H, Gao X, Li X, "et al." |title=IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19403–10 |year= 1999 |pmid= 10383454 |doi=
*cite journal | author=Yang RB, Mark MR, Gurney AL, Godowski PJ |title=Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. |journal=J. Immunol. |volume=163 |issue= 2 |pages= 639–43 |year= 1999 |pmid= 10395652 |doi=
*cite journal | author=Thomas JA, Allen JL, Tsen M, "et al." |title=Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. |journal=J. Immunol. |volume=163 |issue= 2 |pages= 978–84 |year= 1999 |pmid= 10395695 |doi=
*cite journal | author=Reichwald K, Thiesen J, Wiehe T, "et al." |title=Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. |journal=Mamm. Genome |volume=11 |issue= 3 |pages= 182–90 |year= 2000 |pmid= 10723722 |doi=
*cite journal | author=Burns K, Clatworthy J, Martin L, "et al." |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346–51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038
*cite journal | author=Böl G, Kreuzer OJ, Brigelius-Flohé R |title=Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus. |journal=FEBS Lett. |volume=477 |issue= 1-2 |pages= 73–8 |year= 2000 |pmid= 10899313 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Vig E, Green M, Liu Y, "et al." |title=SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7859–66 |year= 2001 |pmid= 11096118 |doi= 10.1074/jbc.M010399200
*cite journal | author=Li X, Commane M, Jiang Z, Stark GR |title=IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4461–5 |year= 2001 |pmid= 11287640 |doi= 10.1073/pnas.071054198
*cite journal | author=Jensen LE, Whitehead AS |title=IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29037–44 |year= 2001 |pmid= 11397809 |doi= 10.1074/jbc.M103815200
*cite journal | author=Qian Y, Commane M, Ninomiya-Tsuji J, "et al." |title=IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 41661–7 |year= 2001 |pmid= 11518704 |doi= 10.1074/jbc.M102262200

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