PFKL

Phosphofructokinase, liver, also known as PFKL, is a human gene.cite web | title = Entrez Gene: PFKL phosphofructokinase, liver| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5211| accessdate = ]

PBB_Summary
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summary_text = Phosphofructokinase (PFK) is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. Separate genes encode a muscle subunit (M) and a liver subunit (L). PFK from muscle is a homotetramer of M subunits, PFK from liver is a homotetramer of L-subunits, while PFK from platelets can be composed of any tetrameric combination of M and L subunits. The protein encoded by this gene represents the L subunit. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: PFKL phosphofructokinase, liver| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5211| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kahn A, Meienhofer MC, Cottreau D, "et al." |title=Phosphofructokinase (PFK) isozymes in man. I. Studies of adult human tissues. |journal=Hum. Genet. |volume=48 |issue= 1 |pages= 93–108 |year= 1979 |pmid= 156693 |doi=
*cite journal | author=Kristensen T, Lopez R, Prydz H |title=An estimate of the sequencing error frequency in the DNA sequence databases. |journal=DNA Seq. |volume=2 |issue= 6 |pages= 343–6 |year= 1992 |pmid= 1446073 |doi=
*cite journal | author=Wang D, Fang H, Cantor CR, Smith CL |title=A contiguous Not I restriction map of band q22.3 of human chromosome 21. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3222–6 |year= 1992 |pmid= 1565613 |doi=
*cite journal | author=Elson A, Levanon D, Brandeis M, "et al." |title=The structure of the human liver-type phosphofructokinase gene. |journal=Genomics |volume=7 |issue= 1 |pages= 47–56 |year= 1990 |pmid= 2139864 |doi=
*cite journal | author=Levanon D, Danciger E, Dafni N, "et al." |title=The primary structure of human liver type phosphofructokinase and its comparison with other types of PFK. |journal=DNA |volume=8 |issue= 10 |pages= 733–43 |year= 1990 |pmid= 2533063 |doi=
*cite journal | author=Van Keuren M, Drabkin H, Hart I, "et al." |title=Regional assignment of human liver-type 6-phosphofructokinase to chromosome 21q22.3 by using somatic cell hybrids and a monoclonal anti-L antibody. |journal=Hum. Genet. |volume=74 |issue= 1 |pages= 34–40 |year= 1986 |pmid= 2944814 |doi=
*cite journal | author=Levanon D, Danciger E, Dafni N, Groner Y |title=Genomic clones of the human liver-type phosphofructokinase. |journal=Biochem. Biophys. Res. Commun. |volume=141 |issue= 1 |pages= 374–80 |year= 1987 |pmid= 2948503 |doi=
*cite journal | author=Vora S, Davidson M, Seaman C, "et al." |title=Heterogeneity of the molecular lesions in inherited phosphofructokinase deficiency. |journal=J. Clin. Invest. |volume=72 |issue= 6 |pages= 1995–2006 |year= 1984 |pmid= 6227635 |doi=
*cite journal | author=Vora S, Seaman C, Durham S, Piomelli S |title=Isozymes of human phosphofructokinase: identification and subunit structural characterization of a new system. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=77 |issue= 1 |pages= 62–6 |year= 1980 |pmid= 6444721 |doi=
*cite journal | author=Koster JF, Slee RG, Van Berkel TJ |title=Isoenzymes of human phosphofructokinase. |journal=Clin. Chim. Acta |volume=103 |issue= 2 |pages= 169–73 |year= 1980 |pmid= 6445244 |doi=
*cite journal | author=Vora S, Francke U |title=Assignment of the human gene for liver-type 6-phosphofructokinase isozyme (PFKL) to chromosome 21 by using somatic cell hybrids and monoclonal anti-L antibody. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=78 |issue= 6 |pages= 3738–42 |year= 1981 |pmid= 6455664 |doi=
*cite journal | author=Zeitschel U, Bigl M, Eschrich K, Bigl V |title=Cellular distribution of 6-phosphofructo-1-kinase isoenzymes in rat brain. |journal=J. Neurochem. |volume=67 |issue= 6 |pages= 2573–80 |year= 1996 |pmid= 8931492 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Zhang C, Dowd DR, Staal A, "et al." |title=Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35325–36 |year= 2003 |pmid= 12840015 |doi= 10.1074/jbc.M305191200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046

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