PRKAG2

Protein kinase, AMP-activated, gamma 2 non-catalytic subunit, also known as PRKAG2, is a human gene.cite web | title = Entrez Gene: PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51422| accessdate = ]

PBB_Summary
section_title =
summary_text = AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51422| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gollob MH, Green MS, Tang AS, Roberts R |title=PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy. |journal=Curr. Opin. Cardiol. |volume=17 |issue= 3 |pages= 229–34 |year= 2002 |pmid= 12015471 |doi=
*cite journal | author=Gollob MH |title=Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome. |journal=Biochem. Soc. Trans. |volume=31 |issue= Pt 1 |pages= 228–31 |year= 2003 |pmid= 12546691 |doi= 10.1042/
*cite journal | author=Ofir M, Hochhauser E, Vidne BA, "et al." |title= [AMP-activated protein kinase: how a mistake in energy gauge causes glycogen storage] |journal=Harefuah |volume=146 |issue= 10 |pages= 770–5, 813–4 |year= 2007 |pmid= 17990392 |doi=
*cite journal | author=Hofmann B, Nishanian P, Baldwin RL, "et al." |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=
*cite journal | author=MacRae CA, Ghaisas N, Kass S, "et al." |title=Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3. |journal=J. Clin. Invest. |volume=96 |issue= 3 |pages= 1216–20 |year= 1995 |pmid= 7657794 |doi=
*cite journal | author=Hofmann B, Nishanian P, Nguyen T, "et al." |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=
*cite journal | author=Hofmann B, Nishanian P, Fan J, "et al." |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=
*cite journal | author=Stapleton D, Mitchelhill KI, Gao G, "et al." |title=Mammalian AMP-activated protein kinase subfamily. |journal=J. Biol. Chem. |volume=271 |issue= 2 |pages= 611–4 |year= 1996 |pmid= 8557660 |doi=
*cite journal | author=Gao G, Fernandez CS, Stapleton D, "et al." |title=Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. |journal=J. Biol. Chem. |volume=271 |issue= 15 |pages= 8675–81 |year= 1996 |pmid= 8621499 |doi=
*cite journal | author=Swingler S, Gallay P, Camaur D, "et al." |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi=
*cite journal | author=Stapleton D, Woollatt E, Mitchelhill KI, "et al." |title=AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. |journal=FEBS Lett. |volume=409 |issue= 3 |pages= 452–6 |year= 1997 |pmid= 9224708 |doi=
*cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=
*cite journal | author=Zidovetzki R, Wang JL, Chen P, "et al." |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825–33 |year= 1998 |pmid= 9671211 |doi=
*cite journal | author=Mayne M, Bratanich AC, Chen P, "et al." |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Cheung PC, Salt IP, Davies SP, "et al." |title=Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. |journal=Biochem. J. |volume=346 Pt 3 |issue= |pages= 659–69 |year= 2000 |pmid= 10698692 |doi=
*cite journal | author=Lang T, Yu L, Tu Q, "et al." |title=Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36. |journal=Genomics |volume=70 |issue= 2 |pages= 258–63 |year= 2001 |pmid= 11112354 |doi= 10.1006/geno.2000.6376
*cite journal | author=Blair E, Redwood C, Ashrafian H, "et al." |title=Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. |journal=Hum. Mol. Genet. |volume=10 |issue= 11 |pages= 1215–20 |year= 2001 |pmid= 11371514 |doi=
*cite journal | author=Gollob MH, Green MS, Tang AS, "et al." |title=Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. |journal=N. Engl. J. Med. |volume=344 |issue= 24 |pages= 1823–31 |year= 2001 |pmid= 11407343 |doi=
*cite journal | author=Hamilton SR, Stapleton D, O'Donnell JB, "et al." |title=An activating mutation in the gamma1 subunit of the AMP-activated protein kinase. |journal=FEBS Lett. |volume=500 |issue= 3 |pages= 163–8 |year= 2001 |pmid= 11445078 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes