FBXW7

F-box and WD repeat domain containing 7, also known as FBXW7, is a human gene.cite web | title = Entrez Gene: FBXW7 F-box and WD repeat domain containing 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55294| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.cite web | title = Entrez Gene: FBXW7 F-box and WD repeat domain containing 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55294| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Gupta-Rossi N, Le Bail O, Gonen H, "et al." |title=Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34371–8 |year= 2001 |pmid= 11425854 |doi= 10.1074/jbc.M101343200
*cite journal | author=Oberg C, Li J, Pauley A, "et al." |title=The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35847–53 |year= 2001 |pmid= 11461910 |doi= 10.1074/jbc.M103992200
*cite journal | author=Koepp DM, Schaefer LK, Ye X, "et al." |title=Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. |journal=Science |volume=294 |issue= 5540 |pages= 173–7 |year= 2001 |pmid= 11533444 |doi= 10.1126/science.1065203
*cite journal | author=Moberg KH, Bell DW, Wahrer DC, "et al." |title=Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. |journal=Nature |volume=413 |issue= 6853 |pages= 311–6 |year= 2001 |pmid= 11565033 |doi= 10.1038/35095068
*cite journal | author=Strohmaier H, Spruck CH, Kaiser P, "et al." |title=Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. |journal=Nature |volume=413 |issue= 6853 |pages= 316–22 |year= 2001 |pmid= 11565034 |doi= 10.1038/35095076
*cite journal | author=Wu G, Lyapina S, Das I, "et al." |title=SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7403–15 |year= 2001 |pmid= 11585921 |doi= 10.1128/MCB.21.21.7403-7415.2001
*cite journal | author=Spruck CH, Strohmaier H, Sangfelt O, "et al." |title=hCDC4 gene mutations in endometrial cancer. |journal=Cancer Res. |volume=62 |issue= 16 |pages= 4535–9 |year= 2002 |pmid= 12183400 |doi=
*cite journal | author=Li J, Pauley AM, Myers RL, "et al." |title=SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production. |journal=J. Neurochem. |volume=82 |issue= 6 |pages= 1540–8 |year= 2002 |pmid= 12354302 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Staropoli JF, McDermott C, Martinat C, "et al." |title=Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. |journal=Neuron |volume=37 |issue= 5 |pages= 735–49 |year= 2003 |pmid= 12628165 |doi=
*cite journal | author=Calhoun ES, Jones JB, Ashfaq R, "et al." |title=BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. |journal=Am. J. Pathol. |volume=163 |issue= 4 |pages= 1255–60 |year= 2003 |pmid= 14507635 |doi=
*cite journal | author=Welcker M, Singer J, Loeb KR, "et al." |title=Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. |journal=Mol. Cell |volume=12 |issue= 2 |pages= 381–92 |year= 2003 |pmid= 14536078 |doi=
*cite journal | author=Busino L, Donzelli M, Chiesa M, "et al." |title=Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. |journal=Nature |volume=426 |issue= 6962 |pages= 87–91 |year= 2003 |pmid= 14603323 |doi= 10.1038/nature02082
*cite journal | author=Cassia R, Moreno-Bueno G, Rodríguez-Perales S, "et al." |title=Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma. |journal=J. Pathol. |volume=201 |issue= 4 |pages= 589–95 |year= 2004 |pmid= 14648662 |doi= 10.1002/path.1474
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Nateri AS, Riera-Sans L, Da Costa C, Behrens A |title=The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. |journal=Science |volume=303 |issue= 5662 |pages= 1374–8 |year= 2004 |pmid= 14739463 |doi= 10.1126/science.1092880

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