STK10

Serine/threonine kinase 10, also known as STK10, is a human gene.cite web | title = Entrez Gene: STK10 serine/threonine kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6793| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.cite web | title = Entrez Gene: STK10 serine/threonine kinase 10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6793| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kuramochi S, Moriguchi T, Kuida K, "et al." |title=LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22679–84 |year= 1997 |pmid= 9278426 |doi=
*cite journal | author=Kuramochi S, Matsuda Y, Okamoto M, "et al." |title=Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues. |journal=Immunogenetics |volume=49 |issue= 5 |pages= 369–75 |year= 1999 |pmid= 10199912 |doi=
*cite journal | author=Tao L, Wadsworth S, Mercer J, "et al." |title=Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. |journal=Biochem. J. |volume=363 |issue= Pt 1 |pages= 175–82 |year= 2002 |pmid= 11903060 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Walter SA, Cutler RE, Martinez R, "et al." |title=Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18221–8 |year= 2003 |pmid= 12639966 |doi= 10.1074/jbc.M212556200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Bignell G, Smith R, Hunter C, "et al." |title=Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. |journal=Genes Chromosomes Cancer |volume=45 |issue= 1 |pages= 42–6 |year= 2006 |pmid= 16175573 |doi= 10.1002/gcc.20265
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240
*cite journal | author=Wissing J, Jänsch L, Nimtz M, "et al." |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200

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