RPS6KB2

RPS6KB2

Ribosomal protein S6 kinase, 70kDa, polypeptide 2, also known as RPS6KB2, is a human gene.cite web | title = Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6199| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.cite web | title = Entrez Gene: RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6199| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gout I, Minami T, Hara K, "et al." |title=Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30061–4 |year= 1998 |pmid= 9804755 |doi=
*cite journal | author=Saitoh M, ten Dijke P, Miyazono K, Ichijo H |title=Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 470–6 |year= 1999 |pmid= 9878560 |doi= 10.1006/bbrc.1998.9784
*cite journal | author=Lee-Fruman KK, Kuo CJ, Lippincott J, "et al." |title=Characterization of S6K2, a novel kinase homologous to S6K1. |journal=Oncogene |volume=18 |issue= 36 |pages= 5108–14 |year= 1999 |pmid= 10490847 |doi= 10.1038/sj.onc.1202894
*cite journal | author=Koh H, Jee K, Lee B, "et al." |title=Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt. |journal=Oncogene |volume=18 |issue= 36 |pages= 5115–9 |year= 1999 |pmid= 10490848 |doi= 10.1038/sj.onc.1202895
*cite journal | author=Martin KA, Schalm SS, Richardson C, "et al." |title=Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase pathway. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7884–91 |year= 2001 |pmid= 11108711 |doi= 10.1074/jbc.M006969200
*cite journal | author=Martin KA, Schalm SS, Romanelli A, "et al." |title=Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7892–8 |year= 2001 |pmid= 11108720 |doi= 10.1074/jbc.M009972200
*cite journal | author=Minami T, Hara K, Oshiro N, "et al." |title=Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha. |journal=Genes Cells |volume=6 |issue= 11 |pages= 1003–15 |year= 2002 |pmid= 11733037 |doi=
*cite journal | author=Pardo OE, Arcaro A, Salerno G, "et al." |title=Novel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cells. |journal=Oncogene |volume=20 |issue= 52 |pages= 7658–67 |year= 2002 |pmid= 11753643 |doi= 10.1038/sj.onc.1204994
*cite journal | author=Park IH, Bachmann R, Shirazi H, Chen J |title=Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31423–9 |year= 2002 |pmid= 12087098 |doi= 10.1074/jbc.M204080200
*cite journal | author=Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T, "et al." |title=Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells-a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells. |journal=Arch. Biochem. Biophys. |volume=405 |issue= 1 |pages= 21–31 |year= 2002 |pmid= 12176053 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Valovka T, Verdier F, Cramer R, "et al." |title=Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization. |journal=Mol. Cell. Biol. |volume=23 |issue= 3 |pages= 852–63 |year= 2003 |pmid= 12529391 |doi=
*cite journal | author=Levy Y, Ronen D, Bershadsky AD, Zick Y |title=Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14533–42 |year= 2003 |pmid= 12569102 |doi= 10.1074/jbc.M207380200
*cite journal | author=Phin S, Kupferwasser D, Lam J, Lee-Fruman KK |title=Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1. |journal=Biochem. J. |volume=373 |issue= Pt 2 |pages= 583–91 |year= 2003 |pmid= 12713446 |doi= 10.1042/BJ20021794
*cite journal | author=Kanayasu-Toyoda T, Yamaguchi T, Oshizawa T, "et al." |title=The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells. |journal=Biochem. Pharmacol. |volume=66 |issue= 1 |pages= 133–40 |year= 2003 |pmid= 12818373 |doi=
*cite journal | author=An WL, Cowburn RF, Li L, "et al." |title=Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 591–607 |year= 2003 |pmid= 12875979 |doi=
*cite journal | author=Shao J, Evers BM, Sheng H |title=Roles of phosphatidylinositol 3'-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial cells. |journal=Cancer Res. |volume=64 |issue= 1 |pages= 229–35 |year= 2004 |pmid= 14729629 |doi=
*cite journal | author=Lekmine F, Sassano A, Uddin S, "et al." |title=Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. |journal=Exp. Cell Res. |volume=295 |issue= 1 |pages= 173–82 |year= 2004 |pmid= 15051500 |doi= 10.1016/j.yexcr.2003.12.021
*cite journal | author=Raught B, Peiretti F, Gingras AC, "et al." |title=Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. |journal=EMBO J. |volume=23 |issue= 8 |pages= 1761–9 |year= 2005 |pmid= 15071500 |doi= 10.1038/sj.emboj.7600193
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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