RPS4X

Ribosomal protein S4, X-linked, also known as RPS4X, is a human gene.cite web | title = Entrez Gene: RPS4X ribosomal protein S4, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6191| accessdate = ]

PBB_Summary
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summary_text = Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.cite web | title = Entrez Gene: RPS4X ribosomal protein S4, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6191| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=
*cite journal | author=Watanabe M, Furuno N, Goebl M, "et al." |title=Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene. |journal=J. Cell. Sci. |volume=100 ( Pt 1) |issue= |pages= 35–43 |year= 1992 |pmid= 1795030 |doi=
*cite journal | author=Fisher EM, Beer-Romero P, Brown LG, "et al." |title=Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. |journal=Cell |volume=63 |issue= 6 |pages= 1205–18 |year= 1991 |pmid= 2124517 |doi=
*cite journal | author=Wiles MV, Alexander CM, Goodfellow PN |title=Isolation of an abundantly expressed sequence from the human X chromosome by differential screening. |journal=Somat. Cell Mol. Genet. |volume=14 |issue= 1 |pages= 31–9 |year= 1988 |pmid= 2829364 |doi=
*cite journal | author=Matoba R, Okubo K, Hori N, "et al." |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Zinn AR, Alagappan RK, Brown LG, "et al." |title=Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2485–92 |year= 1994 |pmid= 8139551 |doi=
*cite journal | author=Watanabe M, Zinn AR, Page DC, Nishimoto T |title=Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome. |journal=Nat. Genet. |volume=4 |issue= 3 |pages= 268–71 |year= 1993 |pmid= 8358435 |doi= 10.1038/ng0793-268
*cite journal | author=Geerkens C, Just W, Held KR, Vogel W |title=Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X. |journal=Hum. Genet. |volume=97 |issue= 1 |pages= 39–44 |year= 1996 |pmid= 8557258 |doi=
*cite journal | author=Vladimirov SN, Ivanov AV, Karpova GG, "et al." |title=Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. |journal=Eur. J. Biochem. |volume=239 |issue= 1 |pages= 144–9 |year= 1996 |pmid= 8706699 |doi=
*cite journal | author=Omoe K, Endo A |title=Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs. |journal=Genomics |volume=31 |issue= 1 |pages= 44–50 |year= 1996 |pmid= 8808278 |doi= 10.1006/geno.1996.0007
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kenmochi N, Kawaguchi T, Rozen S, "et al." |title=A map of 75 human ribosomal protein genes. |journal=Genome Res. |volume=8 |issue= 5 |pages= 509–23 |year= 1998 |pmid= 9582194 |doi=
*cite journal | author=Uechi T, Tanaka T, Kenmochi N |title=A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. |journal=Genomics |volume=72 |issue= 3 |pages= 223–30 |year= 2001 |pmid= 11401437 |doi= 10.1006/geno.2000.6470
*cite journal | author=Robinson RC, Turbedsky K, Kaiser DA, "et al." |title=Crystal structure of Arp2/3 complex. |journal=Science |volume=294 |issue= 5547 |pages= 1679–84 |year= 2001 |pmid= 11721045 |doi= 10.1126/science.1066333
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384–96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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