Nucleotidyltransferase

Nucleotidyltransferases are transferase enzymes of phosphorus-containing groups, e.g., substituents of nucleotidylic acids or simply nucleoside monophosphates. The general reaction of transferring a nucleoside monophosphate moiety from A to B, can be written as:

A-P-N + B $\rightleftharpoons$ A + B-P-N

For example, in the case of polymerases, A is pyrophosphate and B is the nascent polynucleotide. They are classified under EC number 2.7.7 and they can be categorised into:

1. Uridylyltransferases, which transfer uridylyl- groups
2. Adenylyltransferases, which transfer adenylyl- groups
3. Guanylyltransferases, which transfer guanylyl- groups
4. Cytitidylyltransferases, which transfer cytidylyl- groups
5. Thymidylyltransferases, which transfer thymidylyl- groups

Role DNA repair mechanisms

Nucleotidyl transferase is a component of the repair pathway for single nucleotide base excision repair. This repair mechanism begins when a single nucleotide is recognized by DNA glycosylase as incorrectly matched or has been mutated in some way (UV light, chemical mutagen, etc.), and is removed. Later, a nucleotidyl tranferase is used to fill in the gap with the correct base, using the template strand as the reference. ^[1]

References

1. ^ Yuan Liu, Rajendra Prasad, William A. Beard, Padmini S. Kedar, Esther W. Hou, David D. Shock, and Samuel H. Wilson (May 4 2007). "Coordination of Steps in Single-nucleotide Base Excision Repair Mediated by Apurinic/Apyrimidinic Endonuclease 1 and DNA Polymerase beta.". Journal of Biological Chemistry 282 (18): 13532–13541. doi:10.1074/jbc.M611295200. PMC 2366199. PMID 17355977. http://www.jbc.org/content/282/18/13532.full.pdf+html. "The enzymes and accessory factors involved in the BER subpathways in mammalian cells have received considerable attention. As summarized above, five distinct enzymatic reaction are involved during SN-BER. These are 1) removal of a modified base by a lesion-specific monofunctional DNA N-glycosylase, 2) 5'-incision of the abasic site by a hydrolytic strand incision enzyme, 3) DNA synthesis by a nucleotidyltransferase, 4) removal of the 5'-dRP group by a'-elimination reaction, and 5) nick sealing by DNA ligase (36, 37)" 

External links

• MeSH Nucleotidyltransferases

This transferase article is a stub. You can help Wikipedia by expanding it.v · Categories: Transferases EC 2.7.7 Transferase stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР VSO Software Ali Al Bazergan Look at other dictionaries: Nucléotidyltransférase — Les nucléotidyltransférases sont des enzymes phosphotransférases qui agissent sur des composants des nucléotides. Dans la nomenclature EC, ils sont classifiés dans le domaine 2.7.7 Portail de la biochimie …   Wikipédia en Français nucleotidyltransferase — noun Any enzyme that transfers nucleotide residues …   Wiktionary nucleotidyltransferase — nu·cleo·ti·dyl·trans·fer·ase .n(y)ü klē ə tīd əl tran(t)s (.)fər .ās, .āz n any of several enzymes that catalyze the transfer of a nucleotide residue from one compound to another * * * nu·cleo·tid·yl·trans·fer·ase (noo″kle o tidґəl… …   Medical dictionary nucleotidyltransferase — nu·cleo·ti·dyl·transferase …   English syllables nucleotidyltransferase — ¦n(y)üklēə¦tīdəlˌ noun Etymology: nucleotide + yl + transferase : any of several enzymes that catalyze the transfer of a nucleotide residue from one compound to another …   Useful english dictionary Aldose-1-phosphate nucleotidyltransferase — In enzymology, an aldose 1 phosphate nucleotidyltransferase (EC number|2.7.7.37) is an enzyme that catalyzes the chemical reaction:NDP + alpha D aldose 1 phosphate ightleftharpoons phosphate + NDP aldoseThus, the two substrates of this enzyme are …   Wikipedia Nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase — nucleoside triphosphate hexose 1 phosphate nucleotidyltransferase Identifiers EC number 2.7.7.28 CAS number 37278 26 5 …   Wikipedia Gentamicin 2"-nucleotidyltransferase — In enzymology, a gentamicin 2 nucleotidyltransferase (EC number|2.7.7.46) is an enzyme that catalyzes the chemical reaction:nucleoside triphosphate + gentamicin ightleftharpoons diphosphate + 2 nucleotidylgentamicinThus, the two substrates of… …   Wikipedia TRNA nucleotidyltransferase — In enzymology, a tRNA nucleotidyltransferase (EC number|2.7.7.56) is an enzyme that catalyzes the chemical reaction:tRNAn+1 + phosphate ightleftharpoons tRNAn + a nucleoside diphosphateThus, the two substrates of this enzyme are tRNA(n+1) and… …   Wikipedia polyribonucleotide nucleotidyltransferase — An enzyme catalyzing phosphorolysis of polyribonucleotides or of RNA, yielding nucleoside diphosphates (or the reverse, the first artificial polynucleotide formation discovered). SYN: polynucleotide phosphorylase. * * * poly·ri·bo·nu·cleo·tide… …   Medical dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”