Nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase

Nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase
nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase
EC number
CAS number 37278-26-5
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase (EC is an enzyme that catalyzes the chemical reaction

nucleoside triphosphate + alpha-D-aldose 1-phosphate \rightleftharpoons diphosphate + NDP-hexose

Thus, the two substrates of this enzyme are nucleoside triphosphate and alpha-D-aldose 1-phosphate, whereas its two products are diphosphate and NDP-hexose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase. Other names in common use include NDP hexose pyrophosphorylase, hexose 1-phosphate nucleotidyltransferase, hexose nucleotidylating enzyme, nucleoside diphosphohexose pyrophosphorylase, hexose-1-phosphate guanylyltransferase, GTP:alpha-D-hexose-1-phosphate guanylyltransferase, GDP hexose pyrophosphorylase, guanosine diphosphohexose pyrophosphorylase, nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase, and NTP:hexose-1-phosphate nucleotidyltransferase.


  • Verachtert H, Rodriguez P, Bass ST, Hansen RG (1966). "Purification and properties of guanosine diphosphate hexose pyrophosphorylase from mammalian tissues". J. Biol. Chem. 241 (9): 2007–13. PMID 5946626. 
  • Hansen RG, Verachtert H, Rodriguez P and Bass ST (1966). "GDP-hexose pyrophosphorylase from liver". Methods Enzymol.. Methods in Enzymology 8: 269–271. doi:10.1016/0076-6879(66)08048-0. ISBN 9780121818081.